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Radiation Biology and Molecular Radiation Oncology

Section edited by Kirsten Lauber and Horst Zitzelsberger

The Radiation Biology and Molecular Radiation Oncology section aims at providing a platform for biological research and its translation into clinical radiation oncology. This includes innovative studies on the cellular responses towards ionizing irradiation and their underlying mechanisms, technical approaches, identification of biomarkers, and experimental therapy approaches. Submission of studies involving animal models and/or primary, patient-derived samples/material is particularly encouraged. Space is also provided for review contributions on timely topics, as well as invited key reviews from renowned experts. Thus, the Radiation Biology and Molecular Radiation Oncology section addresses current, timely and cutting-edge research and reviews about biologically relevant issues in radiation oncology, while offering a fast review process and broad outreach.

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  1. Content type: Research

    Resistance to radiotherapy is frequently encountered in patients with glioblastoma multiforme. It is caused at least partially by the high glutathione content in the tumour tissue. Therefore, the administratio...

    Authors: E. Schültke, E. Bräuer-Krisch, H. Blattmann, H. Requardt, J. A. Laissue and G. Hildebrandt

    Citation: Radiation Oncology 2018 13:89

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  2. Content type: Research

    The role of adjuvant radiotherapy (RT) and setting proper RT target volumes have not been clearly demonstrated for extrahepatic bile duct (EHBD) cancer, due to the rarity of the disease and the lack of randomi...

    Authors: Hoon Sik Choi, Ki Mun Kang, Bae Kwon Jeong, Hojin Jeong, Yun Hee Lee, In Bong Ha, Tae Gyu Kim and Jin Ho Song

    Citation: Radiation Oncology 2018 13:85

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  3. Content type: Short Report

    Ataxia Telangiectasia and Rad3 related protein (ATR) is a central mediator of the response to DNA damage that may cause the quiescent resistance of cancer initiating cells to genotoxic radiotherapy. NVP-BEZ235...

    Authors: Guido Fròsina, Aldo Profumo, Daniela Marubbi, Diana Marcello, Jean Louis Ravetti and Antonio Daga

    Citation: Radiation Oncology 2018 13:76

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  4. Content type: Research

    The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radi...

    Authors: Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe and Keiichi Nakagawa

    Citation: Radiation Oncology 2018 13:70

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  5. Content type: Research

    The incomplete repair (IR) model expresses the cell repair effect from radiation-induced damage over time, which is given little consideration in actual treatment planning. By incorporating the IR model into t...

    Authors: Yushi Wakisaka, Masashi Yagi, Iori Sumida, Masaaki Takashina, Kazuhiko Ogawa and Masahiko Koizumi

    Citation: Radiation Oncology 2018 13:30

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  6. Content type: Research

    The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the “clinical research group ion beam therapy” funded by the German Research Foun...

    Authors: Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus and Christian P. Karger

    Citation: Radiation Oncology 2018 13:5

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  7. Content type: Research

    As there is a growing number of long-term cancer survivors, the incidence of carcinogenesis as a late effect of radiotherapy is getting more and more into the focus. The risk for the development of secondary m...

    Authors: Dajana Juerß, Monique Zwar, Ulrich Giesen, Ralf Nolte, Stephan Kriesen, Giorgio Baiocco, Monika Puchalska, Marc-Jan van Goethem, Katrin Manda and Guido Hildebrandt

    Citation: Radiation Oncology 2017 12:159

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  8. Content type: Research

    Radiotherapy plays a major role in the management of high grade glioma. However, the radioresistance of glioma cells limits its efficiency and drives recurrence inside the irradiated tumor volume leading to po...

    Authors: Julian Biau, Emmanuel Chautard, Leanne De Koning, Frank Court, Bruno Pereira, Pierre Verrelle and Marie Dutreix

    Citation: Radiation Oncology 2017 12:123

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  9. Content type: Research

    Clinical parameters and proteins have recently been suggested as possible causes of radiotherapy (RT) resistance in cervical carcinoma (CC). The objective of the present study was to validate prognostic biomar...

    Authors: P. Moreno-Acosta, A. Vallard, S. Carrillo, O. Gamboa, A. Romero-Rojas, M. Molano, J. Acosta, D. Mayorga, C. Rancoule, M.A. Garcia, M. Cotes Mestre and N. Magné

    Citation: Radiation Oncology 2017 12:120

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  10. Content type: Research

    Cellular responses to proton beam irradiation are not yet clearly understood, especially differences in the relative biological effectiveness (RBE) of high-energy proton beams depending on the position on the ...

    Authors: Hidehiro Hojo, Takeshi Dohmae, Kenji Hotta, Ryosuke Kohno, Atsushi Motegi, Atsushi Yagishita, Hideki Makinoshima, Katsuya Tsuchihara and Tetsuo Akimoto

    Citation: Radiation Oncology 2017 12:111

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  11. Content type: Review

    Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-sur...

    Authors: Shing Yau Tam, Vincent Wing Cheung Wu and Helen Ka Wai Law

    Citation: Radiation Oncology 2017 12:57

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  12. Content type: Research

    Boron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-a...

    Authors: Gen Futamura, Shinji Kawabata, Naosuke Nonoguchi, Ryo Hiramatsu, Taichiro Toho, Hiroki Tanaka, Shin-Ichiro Masunaga, Yoshihide Hattori, Mitsunori Kirihata, Koji Ono, Toshihiko Kuroiwa and Shin-Ichi Miyatake

    Citation: Radiation Oncology 2017 12:26

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  13. Content type: Research

    In our previous study, monogalactosyl diacylglycerol (MGDG) purified from spinach was found to have cytotoxic effects in human cancer cell lines. This study further assessed whether MGDG can enhance the cytoto...

    Authors: Hiroaki Akasaka, Yoshiyuki Mizushina, Kenji Yoshida, Yasuo Ejima, Naritoshi Mukumoto, Tianyuan Wang, Sachiko Inubushi, Masao Nakayama, Yuki Wakahara and Ryohei Sasaki

    Citation: Radiation Oncology 2016 11:153

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  14. Content type: Research

    Hadron therapy is an innovative technique where cancer cells are precisely killed leaving surrounding healthy cells least affected by high linear energy transfer (LET) radiation like carbon ion beam. Anti-meta...

    Authors: Atanu Ghorai, Asitikantha Sarma, Priyanka Chowdhury and Utpal Ghosh

    Citation: Radiation Oncology 2016 11:126

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  15. Content type: Research

    Intracavitary irradiation plays a pivotal role in definitive radiotherapy for cervical cancer, and the Ir-192 high dose-rate remote afterloading system (HDR-RALS) is often used for this purpose. Under this con...

    Authors: Taito Asahina, Atsushi Kaida, Tatsuaki Goto, Ryo-Ichi Yoshimura, Keisuke Sasai and Masahiko Miura

    Citation: Radiation Oncology 2016 11:99

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  16. Content type: Research

    Acquired and inherent radioresistance of tumor cells is related to tumor relapse and poor prognosis – not only in head and neck squamous cell carcinoma (HNSCC). The underlying molecular mechanisms are largely ...

    Authors: Agata Michna, Ulrike Schötz, Martin Selmansberger, Horst Zitzelsberger, Kirsten Lauber, Kristian Unger and Julia Hess

    Citation: Radiation Oncology 2016 11:94

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  17. Content type: Research

    Biological applications of nanoparticles are rapidly increasing, which introduces new possibilities to improve the efficacy of radiotherapy. Here, we synthesized titanium peroxide nanoparticles (TiOxNPs) and i...

    Authors: Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Zhenquan Tan, Yuya Nishimura, Hiroaki Akasaka, Kazuyoshi Sato, Chiya Numako, Seiichi Takami and Akihiko Kondo

    Citation: Radiation Oncology 2016 11:91

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  18. Content type: Research

    O-(2-18 F-fluoroethyl)-L-tyrosine-(FET)-PET may be helpful to improve the definition of radiation target volumes in glioblastomas compared with MRI. We analyzed the relapse patterns in FET-PET after a FET- and...

    Authors: Marc D. Piroth, Norbert Galldiks, Michael Pinkawa, Richard Holy, Gabriele Stoffels, Johannes Ermert, Felix M. Mottaghy, N. Jon Shah, Karl-Josef Langen and Michael J. Eble

    Citation: Radiation Oncology 2016 11:87

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  19. Content type: Research

    Unsaturated fatty acids (FA) are required for cancer cell growth. In normoxia cells can generate unsaturated FA from saturated stearic and palmitic acid by desaturation. However, since the desaturation step is...

    Authors: Johann Matschke, Elisa Wiebeck, Sebastian Hurst, Justine Rudner and Verena Jendrossek

    Citation: Radiation Oncology 2016 11:75

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