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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Content type: Research

    Nutritional status and haematological parameters are related to the prognosis of patients treated with radiotherapy, but the correlation between adaptive radiotherapy (ART) and haematological indicators has ne...

    Authors: Ning Han, Xintong Lyu, Guang Li and Qiao Qiao

    Citation: Radiation Oncology 2019 14:151

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  2. Content type: Research

    The present prospective study evaluated the safety and efficacy of the rectum following KUSHEN Ningjiaos in cervical cancer. We compared rectal wall changes during brachytherapy with or without KUSHEN Ningjiaos i...

    Authors: Xiaojuan Li, Cheng Xiao, Yilin Kong, Weiwei Guo, Wenting Zhan, Gong Li, Xuetao Wang, Bailin Zhang and Lei Gao

    Citation: Radiation Oncology 2019 14:149

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  3. Content type: Methodology

    To evaluate and establish a digital workflow for the custom designing and 3D printing of mouth opening tongue-depressing (MOTD) stents for patients receiving radiotherapy for head and neck cancer.

    Authors: Mohamed Zaid, Nimit Bajaj, Hannah Burrows, Ryan Mathew, Annie Dai, Christopher T. Wilke, Stephen Palasi, Ryan Hergenrother, Caroline Chung, Clifton D. Fuller, Jack Phan, G. Brandon Gunn, William H. Morrison, Adam S. Garden, Steven J. Frank, David I. Rosenthal…

    Citation: Radiation Oncology 2019 14:148

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  4. Content type: Research

    There is continued debate regarding the optimal combinations of radiation therapy and chemotherapy in the preoperative treatment of locally advanced rectal adenocarcinomas. We report our single-institution exp...

    Authors: Angela Y. Jia, Amol Narang, Bashar Safar, Atif Zaheer, Adrian Murphy, Nilofer S. Azad, Susan Gearhart, Sandy Fang, Jonathan Efron, Tam Warczynski, Amy Hacker-Prietz and Jeffrey Meyer

    Citation: Radiation Oncology 2019 14:147

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  5. Content type: Review

    At present, the standard treatment approach for locally advanced cervical cancer is concurrent chemoradiotherapy (CCRT). An elevated pretreatment squamous cell carcinoma antigen (SCC Ag) level is associated wi...

    Authors: Jingxuan Fu, Weiping Wang, Yidan Wang, Chengeng Liu and Peichang Wang

    Citation: Radiation Oncology 2019 14:146

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  6. Content type: Research

    Comparing radiation treatment plans by using the same safety margins and dose objectives for all techniques, to ascertain the optimal radiation technique for the stereotactic body radiotherapy (SBRT) of low-ri...

    Authors: Sergiu Scobioala, Christopher Kittel, Khaled Elsayad, Kai Kroeger, Michael Oertel, Laith Samhouri, Uwe Haverkamp and Hans Theodor Eich

    Citation: Radiation Oncology 2019 14:143

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  7. Content type: Research

    To investigate the prognostic significance of positron emission tomography (PET) parameters from F-18 fluorodeoxyglucose (FDG) PET scans performed pre- and post- chemo-radiotherapy (CRT) for squamous cell carc...

    Authors: Michael Peter Jones, George Hruby, Ur Metser, Swetha Sridharan, Anne Capp, Mahesh Kumar, Sarah Gallagher, Natalie Rutherford, Carl Holder, Christopher Oldmeadow and Jarad Martin

    Citation: Radiation Oncology 2019 14:140

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  8. Content type: Research

    The aim of this study was to explore the impact of including or excluding the ischiorectal fossa (IRF) within the clinical target volume during neoadjuvant chemoradiotherapy (NCRT) using intensity modulated ra...

    Authors: Maxiaowei Song, Jianhao Geng, Lin Wang, Yongheng Li, Xianggao Zhu, Xiaofan Li, Lan Mi, Aiwen Wu, Yifan Peng, Yunfeng Yao, Yangzi Zhang, Hongzhi Wang, Chen Shi, Yong Cai and Weihu Wang

    Citation: Radiation Oncology 2019 14:138

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  9. Content type: Research

    We compared clinical outcomes of carbon ion radiotherapy and transarterial chemoembolization in the treatment of hepatocellular carcinoma.

    Authors: Shintaro Shiba, Kei Shibuya, Hiroyuki Katoh, Takuya Kaminuma, Masaya Miyazaki, Satoru Kakizaki, Ken Shirabe, Tatsuya Ohno and Takashi Nakano

    Citation: Radiation Oncology 2019 14:137

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  10. Content type: Research

    Multiple phase I-II clinical trials have reported on the efficacy and safety of prostate stereotactic body radiotherapy (SBRT) for the treatment of prostate cancer. However, few have reported outcomes for pros...

    Authors: Mark E. Hwang, Mark Mayeda, Maria Liz, Brenda Goode-Marshall, Lissette Gonzalez, Carl D. Elliston, Catherine S. Spina, Oscar A. Padilla, Sven Wenske and Israel Deutsch

    Citation: Radiation Oncology 2019 14:136

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  11. Content type: Research

    Along with breast-conserving surgery (BCS), adjuvant radiotherapy (RT) of patients with early breast cancer plays a crucial role in the oncologic treatment concept. Conventionally, irradiation is carried out w...

    Authors: Michael Mayinger, Kai Joachim Borm, Constantin Dreher, Hendrik Dapper, Marciana-Nona Duma, Markus Oechsner, Severin Kampfer, Stephanie Elisabeth Combs and Daniel Habermehl

    Citation: Radiation Oncology 2019 14:135

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  12. Content type: Research

    Various prognostic factors have been suggested in meningioma patients including WHO grading, brain invasion and bone involvement, for instance. Brain invasion was included as an independent criterion in the re...

    Authors: Kerstin Zwirner, Frank Paulsen, Jens Schittenhelm, Irina Gepfner-Tuma, Ghazaleh Tabatabai, Felix Behling, Marco Skardelly, Benjamin Bender, Daniel Zips and Franziska Eckert

    Citation: Radiation Oncology 2019 14:132

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  13. Content type: Research

    Lacking quantitative evaluations of clinicopathological features and the risk factors for loco-regional recurrence (LRR) in gastric cancer after D2 gastrectomy, we aimed to develop a competing risk nomogram to...

    Authors: Shu-Bei Wang, Wei-Xiang Qi, Jia-Yi Chen, Cheng Xu, Youlia M. Kirova, Wei-Guo Cao, Rong Cai, Lu Cao, Min Yan and Gang Cai

    Citation: Radiation Oncology 2019 14:128

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  14. Content type: Case report

    The role of local radiotherapy in the treatment of metastatic rhabdomyosarcoma is important. However, with peritoneal dissemination, the application of local therapy is challenging. Although there are few repo...

    Authors: Mariko Kawamura, Kuniyasu Okudaira, Yoshiyuki Itoh, Takeshi Kamomae, Eri Nishikawa, Hideki Muramatsu, Yoshiyuki Takahashi, Kazuki Yokota and Shinji Naganawa

    Citation: Radiation Oncology 2019 14:127

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  15. Content type: Research

    Stereotactic ablative radiotherapy (SABR) is a treatment option for patients with early stage non-small cell lung cancer (NSCLC) and recurrent or oligometastatic disease who are not surgical candidates. Due to...

    Authors: Hayley Stowe, Stella Ogake, Sunil Sharma, Suzanne Kelly, Morgan McDonald, Kayla Stanley, Paul Walker, Hyder Arastu, Carlos Anciano Granadillo, Mark Bowling and Andrew Ju

    Citation: Radiation Oncology 2019 14:124

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  16. Content type: Study protocol

    For patients with treatment-naïve carcinoma of the prostate, hypofractionated irradiation becomes more and more popular. Due to the low α/β value of prostate cancer, increased single dose leading to a shortene...

    Authors: Stefan A. Koerber, Sonja Katayama, Anja Sander, Cornelia Jaekel, Matthias F. Haefner, Juergen Debus and Klaus Herfarth

    Citation: Radiation Oncology 2019 14:122

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  17. Content type: Research

    The boost irradiation to the tumor bed following whole-breast irradiation (WBI) reduced the risk of ipsilateral breast tumor recurrence (IBTR). However, in Japan, almost all patients with a margin ≤5 mm receiv...

    Authors: Yuka Ono, Michio Yoshimura, Kimiko Hirata, Chikako Yamauchi, Masakazu Toi, Eiji Suzuki, Masahiro Takada, Masahiro Hiraoka and Takashi Mizowaki

    Citation: Radiation Oncology 2019 14:121

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  18. Content type: Research

    Neoadjuvant chemoradiation or chemotherapy has improved the treatment efficacy of patients with resectable, borderline resectable, and locally advanced pancreatic ductal adenocarcinoma (PDAC). Due to the optim...

    Authors: Qiancheng Hu, Dan Wang, Ye Chen, Xiaofen Li, Peng Cao and Dan Cao

    Citation: Radiation Oncology 2019 14:120

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  19. Content type: Research

    Primary adenoid cystic carcinomas (ACCs) of the trachea are rare tumors of the central bronchial system. In patients presenting with unresectable tumors, severe comorbidities, or incomplete surgical resection,...

    Authors: Benjamin A. Högerle, Felix Lasitschka, Thomas Muley, Nina Bougatf, Klaus Herfarth, Sebastian Adeberg, Martin Eichhorn, Jürgen Debus, Hauke Winter, Stefan Rieken and Matthias Uhl

    Citation: Radiation Oncology 2019 14:117

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  20. Content type: Research

    Systemic inflammation plays a critical role in cancer progression and oncologic outcomes in cancer patients. We investigated whether preoperative inflammatory biomarkers, including C-reactive protein (CRP), er...

    Authors: Geumju Park, Si Yeol Song, Jin-Hee Ahn, Wan-lim Kim, Jong-seok Lee, Seong-Yun Jeong, Jae Won Park, Eun Kyung Choi, Wonsik Choi and In-Hye Jung

    Citation: Radiation Oncology 2019 14:116

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  21. Content type: Research

    To investigate the efficacy and toxicity of concurrent radiation therapy (RT) and paclitaxel in the treatment of unresectable locoregionally recurrent breast cancer (RBC) after mastectomy as primary treatment.

    Authors: Gang Cai, Lu Cao, Youlia M. Kirova, Yan Feng and Jia-Yi Chen

    Citation: Radiation Oncology 2019 14:115

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  22. Content type: Review

    Clinical outcomes for patients with pancreatic adenocarcinoma (PAC) remain dismal. Local recurrences, proportions of margin positive surgical resections, and overall survival outcomes remain inferior in PAC th...

    Authors: William A. Hall and Karyn A. Goodman

    Citation: Radiation Oncology 2019 14:114

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  23. Content type: Research

    To evaluate the cost-effectiveness of preoperative short-course radiotherapy (SCRT, 5 × 5 Gy) plus FOLFOX4 versus long-course oxaliplatin and bolus of fluorouracil based preoperative long-course chemoradiother...

    Authors: Shichao Wang, Feng Wen, Pengfei Zhang, Xin Wang and Qiu Li

    Citation: Radiation Oncology 2019 14:113

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  24. Content type: Research

    Concurrent chemotherapy and radiation using conventional fractionation is the standard treatment for inoperable, locally advanced non-small-cell lung cancer (NSCLC). We tested accelerated hypofractionated radi...

    Authors: Elisabetta Parisi, Giovenzio Genestreti, Anna Sarnelli, Giulia Ghigi, Donatella Arpa, Marco Angelo Burgio, Giampaolo Gavelli, Alice Rossi, Emanuela Scarpi, Manuela Monti, Anna Tesei, Rolando Polico and Antonino Romeo

    Citation: Radiation Oncology 2019 14:112

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  25. Content type: Research

    Incurable inflammatory breast cancer (IBC) patients occasionally suffer from general symptoms such as breast pain, bleeding, ulceration, and discharge, and thus require palliative radiotherapy (RT). Hypofracti...

    Authors: Hoon Sik Choi, Hong Seok Jang, Ki Mun Kang and Byung-ock Choi

    Citation: Radiation Oncology 2019 14:110

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  26. Content type: Research

    The aim of this study was to compare dose-volume histogram (DVH) with dose-mass histogram (DMH) parameters for treatment of left-sided breast cancer in deep inspiration breath-hold (DIBH) and free breathing (F...

    Authors: Markus Oechsner, Mathias Düsberg, Kai Joachim Borm, Stephanie Elisabeth Combs, Jan Jakob Wilkens and Marciana Nona Duma

    Citation: Radiation Oncology 2019 14:109

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  27. Content type: Research

    Consistent results are lacking as regards the comparative effectiveness of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) versus conventional intensity-modulated radiotherapy in pati...

    Authors: Daquan Wang, Nan Bi, Tao Zhang, Zongmei Zhou, Zefen Xiao, Jun Liang, Dongfu Chen, Zhouguang Hui, Jima Lv, Xiaozhen Wang, Xin Wang, Lei Deng, Wenqing Wang, Jingbo Wang, Chunyu Wang, Xiaotong Lu…

    Citation: Radiation Oncology 2019 14:106

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  28. Content type: Research

    Despite recent advances in multimodal treatments, the prognosis of patients with glioblastoma multiforme (GBM) remains poor. The aim of this study was to evaluate the efficacy of moderately hypofractionated si...

    Authors: Liangzhi Zhong, Lu Chen, Shengqing Lv, Qingrui Li, Guangpeng Chen, Wen Luo, Pu Zhou and Guanghui Li

    Citation: Radiation Oncology 2019 14:104

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  29. Content type: Research

    Radiation treatment to the regional nodes results in an improvement in survival in breast cancer according to a meta-analysis of randomized trials. However, different volumes were targeted in these studies: br...

    Authors: Jan Haussmann, Wilfried Budach, Balint Tamaskovics, Edwin Bölke, Stefanie Corradini, Freddy-Joel Djiepmo-Njanang, Kai Kammers and Christiane Matuschek

    Citation: Radiation Oncology 2019 14:102

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  30. Content type: Research

    The functional outcome after the treatment of laryngeal cancer is tightly related to the quality of life of affected patients. The aim of this study is to describe the long-term morbidity and functional outcom...

    Authors: Lukas Anschuetz, Mohamed Shelan, Marco Dematté, Adrian D. Schubert, Roland Giger and Olgun Elicin

    Citation: Radiation Oncology 2019 14:101

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  31. Content type: Research

    The data regarding a transposed ovary in intensity-modulated radiotherapy (IMRT) are not sufficient. Here we aim to investigate the adequate dose constraint of ovarian transposition before radiotherapy in cerv...

    Authors: Lina Yin, Saiquan Lu, Jun Zhu, Weiling Zhang and Guihao Ke

    Citation: Radiation Oncology 2019 14:100

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  32. Content type: Research

    Determining the appropriate gross tumor volume is important for irradiation planning in addition to palliative radiation for bone metastases. While irradiation planning is commonly performed using simulation c...

    Authors: Yuki Wada, Akira Anbai, Satoshi Kumagai, Eriko Okuyama, Kento Hatakeyama, Noriko Takagi and Manabu Hashimoto

    Citation: Radiation Oncology 2019 14:98

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  33. Content type: Research

    The aim of this study was to assess the correlations between the levels of blood glucose (BG) and the dose of radiation therapy (RT) to the central gustatory system (GS) in glioblastoma multiforme (GBM) patients.

    Authors: Marciana N. Duma, Nadja I. Oszfolk, Tobias Boeckh-Behrens, Markus Oechsner, Claus Zimmer, Bernhard Meyer, Paul T. Pfluger and Stephanie E. Combs

    Citation: Radiation Oncology 2019 14:97

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  34. Content type: Research

    It is uncertain if whole-pelvic irradiation (WPRT) in addition to dose-escalated prostate bed irradiation (PBRT) improves biochemical progression-free survival (bPFS) after prostatectomy for locally advanced t...

    Authors: Carola Link, Patrick Honeck, Akiko Makabe, Frank Anton Giordano, Christian Bolenz, Joerg Schaefer, Markus Bohrer, Frank Lohr, Frederik Wenz and Daniel Buergy

    Citation: Radiation Oncology 2019 14:96

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  35. Content type: Research

    To assess toxicity and quality-of-life (QOL) after carbon ion radiotherapy (CIRT) at the Shanghai Proton and Heavy Ion Center (SPHIC) and identify clinical factors that correlate with urinary, bowel and sexual...

    Authors: Yafang Zhang, Ping Li, Qi Yu, Shuang Wu, Xue Chen, Qing Zhang and Shen Fu

    Citation: Radiation Oncology 2019 14:94

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  36. Content type: Review

    Magnetic Resonance-guided radiotherapy (MRgRT) marks the beginning of a new era. MR is a versatile and suitable imaging modality for radiotherapy, as it enables direct visualization of the tumor and the surrou...

    Authors: S. Corradini, F. Alongi, N. Andratschke, C. Belka, L. Boldrini, F. Cellini, J. Debus, M. Guckenberger, J. Hörner-Rieber, F. J. Lagerwaard, R. Mazzola, M. A. Palacios, M. E. P. Philippens, C. P. J. Raaijmakers, C. H. J. Terhaard, V. Valentini…

    Citation: Radiation Oncology 2019 14:92

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  37. Content type: Research

    Although circular collimator arcs (CCA) and dynamic conformal arcs (DCA) are commonly used linear accelerator-based treatment planning techniques for intracranial stereotactic radiosurgery (SRS) of a small sin...

    Authors: Yongsook C. Lee and Yongbok Kim

    Citation: Radiation Oncology 2019 14:91

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  38. Content type: Research

    To evaluate the practicality of NS-21 cream with regard to its skin-related toxicity in patients with head and neck cancer (HNC) who are undergoing concurrent chemoradiation therapy (CCRT) or radiotherapy (RT).

    Authors: Hsiu-Ling Chou, Pei-Wei Shueng, Li-Jen Liao, Chen-Xiong Hsu, Deng-Yu Kuo, Wu-Chia Lo, Pei-Yu Hou, Li-Ying Wang, San-Fang Chou and Chen-Hsi Hsieh

    Citation: Radiation Oncology 2019 14:90

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  39. Content type: Research

    This study set out to evaluate the effect of dose rate on normal tissues (the lung, in particular) and the variation in the treatment efficiency as determined by the monitor unit (MU) and energy applied in Lin...

    Authors: Jaeman Son, Noorie Choi, Jung-in Kim, Jong Min Park, Hong-Gyun Wu, Hyun-Cheol Kang and Chang Heon Choi

    Citation: Radiation Oncology 2019 14:87

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  40. Content type: Research

    To investigate the potential impact of fractionation regimes and overall treatment time (OTT) on lymphopenia during definitive radiotherapy (RT) and its associations with patient outcomes in non-small cell lun...

    Authors: Qianqian Zhao, Gang Chen, Luxi Ye, Shiming Shi, Shisuo Du, Zhaochong Zeng and Jian He

    Citation: Radiation Oncology 2019 14:86

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  41. Content type: Research

    The prognostic significance of radiation dose to the lung or heart is unknown in esophageal cancer patients receiving neoadjuvant chemoradiotherapy followed by surgery (trimodal therapy). This study aimed to d...

    Authors: Jhen-Bin Lin, Li-Chung Hung, Ching-Yuan Cheng, Yu-An Chien, Chou-Hsien Lee, Chia-Chun Huang, Tsai-Wei Chou, Ming-Huei Ko, Yuan-Chun Lai, Mu-Tai Liu, Tung-Hao Chang, Jie Lee and Yu-Jen Chen

    Citation: Radiation Oncology 2019 14:85

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  42. Content type: Review

    Radiation or radiochemotherapy is a common adjuvant therapy for gastric cancer. Intensity-modulated radiation therapy (IMRT) has been demonstrated to provide better dose conformity, allowing dose escalation an...

    Authors: Fang Ren, Shaodan Li, Yin Zhang, Zhifei Zhao, Haiming Wang, Yixin Cui and Maoyun Wang

    Citation: Radiation Oncology 2019 14:84

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  43. Content type: Research

    Low-level laser therapy (LLLT) also called Photobiomodulation therapy (PBMT) could reduce oral mucositis (OM) incidence and severity in head and neck cancer patients treated by chemoradiotherapy, however rando...

    Authors: Florence Legouté, René-Jean Bensadoun, Valérie Seegers, Yoann Pointreau, Delphine Caron, Philippe Lang, Alain Prévost, Laurent Martin, Ulrike Schick, Benjamin Morvant, Olivier Capitain, Gilles Calais and Eric Jadaud

    Citation: Radiation Oncology 2019 14:83

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  44. Content type: Research

    The clinical efficacy of definitive pelvic radiotherapy for primary tumors in patients with newly diagnosed organ metastatic cervical cancer is unclear. Therefore, we conducted a retrospective study to evaluat...

    Authors: Zhuomin Yin, Hanmei Lou, Huarong Tang, Juan Ni, Qiong Zhou and Ming Chen

    Citation: Radiation Oncology 2019 14:82

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  45. Content type: Research

    The impact of sex on prognosis of patients with esophageal squamous cell cancer (ESCC) who underwent definitive radiotherapy remained unclear. The present study aimed to determine the impact of sex on the prog...

    Authors: He-San Luo, Hong-Yao Xu, Ze-Sen Du, Xu-Yuan Li, Sheng-Xi Wu, He-Cheng Huang and Lian-Xing Lin

    Citation: Radiation Oncology 2019 14:74

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  46. Content type: Review

    Different studies have proved in recent years that hypofractionated radiotherapy (RT) improves overall survival of patients affected by locally advanced, unresectable, pancreatic cancer.

    Authors: Luca Boldrini, Davide Cusumano, Francesco Cellini, Luigi Azario, Gian Carlo Mattiucci and Vincenzo Valentini

    Citation: Radiation Oncology 2019 14:71

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