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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Content type: Research

    The aim was to evaluate the outcome, especially locoregional control of patients with locally advanced salivary gland carcinoma (SGC) with perineural spread (Pn1) and/or positive resection margins (R1/2) after...

    Authors: Marlen Haderlein, Claudia Scherl, Sabine Semrau, Sebastian Lettmaier, Markus Hecht, Florian Putz, Heinrich Iro, Abbas Agaimy and Rainer Fietkau

    Citation: Radiation Oncology 2019 14:68

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  2. Content type: Research

    Multimodal treatment with neoadjuvant chemoradiation followed by surgery (nCRT + S) is the treatment of choice for patients with locally advanced or node-positive esophageal squamous cell carcinoma (E-SCC). Th...

    Authors: Stefan Münch, Steffi U. Pigorsch, Michal Devečka, Hendrik Dapper, Marcus Feith, Helmut Friess, Wilko Weichert, Moritz Jesinghaus, Rickmer Braren, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2019 14:66

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  3. Content type: Research

    The differential diagnosis between radiation necrosis, tumor recurrence and tumor progression is crucial for the evaluation of treatment response and treatment planning.

    Authors: Rosa Morabito, Concetta Alafaci, Stefano Pergolizzi, Antonio Pontoriero, Giuseppe Iati’, Lilla Bonanno, Michele Gaeta, Francesco Maria Salpietro, Enricomaria Mormina, Marcello Longo and Francesca Granata

    Citation: Radiation Oncology 2019 14:65

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  4. Content type: Research

    Patients with plasma-cell neoplasia usually suffer from systemic disease, although a minority (< 5%) may present with solitary involvement of bone or soft tissue (extramedullary plasmacytoma (EMP)). Radiothera...

    Authors: Michael Oertel, Khaled Elsayad, Kai Jannes Kroeger, Uwe Haverkamp, Claudia Rudack, Georg Lenz and Hans Theodor Eich

    Citation: Radiation Oncology 2019 14:63

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  5. Content type: Research

    This study investigated the impact of post-radiation sinusitis on the prognosis of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT).

    Authors: Chih-Jen Huang, Ming-Yii Huang, Ming-Chen Paul Shih, Kai-yuan Cheng, Ka-Wo Lee, Tzu-Ying Lu, Shyng-Shiou Yuan and Pen-Tzu Fang

    Citation: Radiation Oncology 2019 14:61

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  6. Content type: Research

    Although there have been many attempts to increase the therapeutic ratio of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma (MALToma), only a few planning studies have reported the efficacy...

    Authors: Seo Hee Choi, So Hyun Park, Jason Joon Bock Lee, Jong Geol Baek, Jin Sung Kim and Hong In Yoon

    Citation: Radiation Oncology 2019 14:59

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  7. Content type: Review

    Advanced pelvic radiotherapy techniques aim to reduce late bowel toxicity which can severely impact the lives of pelvic cancer survivors. Although advanced techniques have been largely adopted worldwide, to ac...

    Authors: Rashmi Jadon, Emma Higgins, Louise Hanna, Mererid Evans, Bernadette Coles and John Staffurth

    Citation: Radiation Oncology 2019 14:57

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  8. Content type: Research

    It remains unknown which is the most preferable regimen used concurrently with thoracic radiation for locally advanced non-small cell lung cancer (NSCLC). We performed a network meta-analysis to address this i...

    Authors: Tingting Liu, Zheng He, Jun Dang and Guang Li

    Citation: Radiation Oncology 2019 14:55

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  9. Content type: Research

    To validate and propose revision of the 8th edition American Joint Committee on Cancer (AJCC) clinical staging system for esophageal squamous cell cancer (ESCC) patients treated with definitive intensity-modul...

    Authors: Mingqiu Chen, Xiqing Li, Yuangui Chen, Pingping Liu, Zhiwei Chen, Minmin Shen, Xiaohong Liu, Yu Lin, Rongqiang Yang, Wei Ni, Xin Zhou, Lurong Zhang, Ye Tian, Junqiang Chen and Lengxi Fu

    Citation: Radiation Oncology 2019 14:54

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  10. Content type: Research

    To clarify the short- and long-term outcomes of radical surgery after neoadjuvant chemoradiotherapy (NCRT) with TS-1 and irinotecan, which enhances radiosensitivity, in patients with locally advanced rectal ca...

    Authors: Takatoshi Nakamura, Takeo Sato, Kazushige Hayakawa, Wasaburou Koizumi, Yuji Kumagai and Masahiko Watanabe

    Citation: Radiation Oncology 2019 14:53

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  11. Content type: Study protocol

    Few patients with pancreatic cancer may be candidates for immediate surgical resection at the initial diagnosis. Even if patients with borderline resectable pancreatic cancer (BRPC), micrometastases may occur ...

    Authors: Suizhi Gao, Xiaofei Zhu, Xiaohan Shi, Kai Cao, Yun Bian, Hui Jiang, Kaixuan Wang, Shiwei Guo, Huojun Zhang and Gang Jin

    Citation: Radiation Oncology 2019 14:52

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  12. Content type: Research

    Immunotherapy is currently being examined as a treatment modality for glioblastoma. Maintaining an optimal total lymphocyte count (TLC) after radiotherapy (RT) and using temozolomide may be beneficial in optim...

    Authors: Hwa Kyung Byun, Nalee Kim, Hong In Yoon, Seok-Gu Kang, Se Hoon Kim, Jaeho Cho, Jong Geol Baek, Jong Hee Chang and Chang-Ok Suh

    Citation: Radiation Oncology 2019 14:51

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  13. Content type: Research

    Child-Turcotte-Pugh (CTP) score extensively used to assess hepatic function, predicting postoperative outcome of hepatocellular carcinoma (HCC) patients. Lately, the albumin–bilirubin (ALBI) grade has been ide...

    Authors: Ting-Shi Su, Hai-Ming Yang, Ying Zhou, Yong Huang, Ping Liang, Tao Cheng, Long Chen, Le-Qun Li and Shi-Xiong Liang

    Citation: Radiation Oncology 2019 14:50

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  14. Content type: Research

    Literature has shown a significant relationship between radiation dose to the larynx and swallowing disorders. We prospectively studied the dose-volume relationship for larynx substructures and aspiration.

    Authors: Katarina G. Petras, Alfred W. Rademaker, Tamer Refaat, Mehee Choi, Tarita O. Thomas, Barbara R. Pauloski and Bharat B. Mittal

    Citation: Radiation Oncology 2019 14:49

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  15. Content type: Research

    To investigate the safety and tolerability of simultaneous integrated boost (SIB) technique concurrent with elective nodal irradiation (ENI) and dual-drug chemotherapy for patients with unresectable esophageal...

    Authors: Chen Li, Wenjie Ni, Xin Wang, Zongmei Zhou, Wei Deng, Xiao Chang, Dongfu Chen, Qinfu Feng, Jun Liang, Xiaozhen Wang, Lei Deng, Wenqing Wang, Nan Bi, Tao Zhang and Zefen Xiao

    Citation: Radiation Oncology 2019 14:48

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  16. Content type: Research

    Rectal spacers are used to limit dose to the anterior rectal wall in high dose external beam radiation therapy of the prostate and have been shown to reduce radiation induced toxicity. Here we report the compl...

    Authors: Andreas Schörghofer, Martin Drerup, Thomas Kunit, Lukas Lusuardi, Josef Holzinger, Josef Karner, Michael Groher, Christoph Zoubek, Rosemarie Forstner, Felix Sedlmayer and Frank Wolf

    Citation: Radiation Oncology 2019 14:47

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  17. Content type: Research

    Administering stereotactic radiotherapy to the surgical cavity and thus omitting postoperative whole brain radiotherapy (WBRT) is a favored strategy in limited metastatic brain disease. Little is known about t...

    Authors: N. Bachmann, D. Leiser, E. Ermis, S. Vulcu, P. Schucht, A. Raabe, D. M. Aebersold and E. Herrmann

    Citation: Radiation Oncology 2019 14:45

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  18. Content type: Research

    Despite development of several next-generation tyrosine kinase inhibitors (TKIs), crizotinib remains one of the first-line treatment options for advanced ALK-positive NSCLC and is widely used in situations where ...

    Authors: Jianjiao Ni, Guodong Li, Xi Yang, Li Chu, Jialei Wang, Yida Li, Liqing Zou, Yuan Li, Congying Xie and Zhengfei Zhu

    Citation: Radiation Oncology 2019 14:44

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  19. Content type: Research

    To develop and compare delta-radiomics signatures from 2- (2D) and 3-dimensional (3D) features that predict treatment outcomes following preoperative chemoradiotherapy (CCRT) and surgery for locally advanced r...

    Authors: Seung Hyuck Jeon, Changhoon Song, Eui Kyu Chie, Bohyoung Kim, Young Hoon Kim, Won Chang, Yoon Jin Lee, Joo-Hyun Chung, Jin Beom Chung, Keun-Wook Lee, Sung-Bum Kang and Jae-Sung Kim

    Citation: Radiation Oncology 2019 14:43

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  20. Content type: Research

    Radiotherapy plays a major role in the management of brain metastases. This study aimed to identify the subset of patients with multiple brain metastases who may not benefit from whole brain irradiation (WBI) ...

    Authors: Rebecca Buecker, Zhen-Yu Hong, Xiao-Mei Liu, Gert Jaenke, Ping Lu and Ulrich Schaefer

    Citation: Radiation Oncology 2019 14:41

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  21. Content type: Research

    To assess the relationship between radiation doses to the coronary arteries (CAs) and location of a coronary stenosis that required intervention after three-dimensional conformal radiotherapy (3DCRT) for breas...

    Authors: Anna-Karin Wennstig, Hans Garmo, Ulf Isacsson, Giovanna Gagliardi, Niina Rintelä, Bo Lagerqvist, Lars Holmberg, Carl Blomqvist, Malin Sund and Greger Nilsson

    Citation: Radiation Oncology 2019 14:40

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  22. Content type: Research

    Arm-lymphedema is a major complication after breast cancer. Recent studies demonstrate the validity of predicting Breast Cancer Related Lymphedema (BCRL) by self-reports. We aimed to investigate the rate of BCRL ...

    Authors: Julia Rupp, Catarina Hadamitzky, Christoph Henkenberens, Hans Christiansen, Diana Steinmann and Frank Bruns

    Citation: Radiation Oncology 2019 14:39

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  23. Content type: Research

    To explore the differences and correlations between the target volumes defined using preoperative prone diagnostic magnetic resonance imaging (MRI) and postoperative prone computed tomography (CT) simulation i...

    Authors: Ting Yu, Jian Bin Li, Wei Wang, Min Xu, Ying Jie Zhang, Qian Shao, Xi Jun Liu and Liang Xu

    Citation: Radiation Oncology 2019 14:38

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  24. Content type: Research

    Subventricular zone (SVZ) involvement is associated with a dismal prognosis in patients with glioblastoma multiforme (GBM). Dual-time point (dtp) O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET/CT (PET) may be a time...

    Authors: Maciej Harat, Bogdan Małkowski and Krzysztof Roszkowski

    Citation: Radiation Oncology 2019 14:37

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  25. Content type: Research

    To evaluate the prognostic value of metabolic parameters of pre-treatment and interim 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for overall survival (OS) of esophageal cancer(EC) patients...

    Authors: Yimin Li, Sebastian Zschaeck, Qin Lin, Sijia Chen, Lili Chen and Hua Wu

    Citation: Radiation Oncology 2019 14:35

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  26. Content type: Research

    Salvage surgery of recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) results in limited local control and survival rates. As a result of recent technological progress, radiotherapy (RT) has ...

    Authors: Sati Akbaba, Thomas Held, Kristin Lang, Juliane Hoerner-Rieber, Karim Zaoui, Tobias Forster, Stefan Rieken, Peter Plinkert, Juergen Debus and Sebastian Adeberg

    Citation: Radiation Oncology 2019 14:34

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  27. Content type: Research

    Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over t...

    Authors: Carsten Nieder, Matthias Guckenberger, Laurie E. Gaspar, Chad G. Rusthoven, Dirk De Ruysscher, Arjun Sahgal, Timothy Nguyen, Anca L. Grosu and Minesh P. Mehta

    Citation: Radiation Oncology 2019 14:33

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  28. Content type: Research

    Concurrent chemoradiotherapy with cisplatin is standard for patients (pts) with loco-regionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) and for patients with resected SCCHN with high-r...

    Authors: Seth Helfenstein, Oliver Riesterer, Urs R. Meier, Alexandros Papachristofilou, Benjamin Kasenda, Miklos Pless and Sacha I. Rothschild

    Citation: Radiation Oncology 2019 14:32

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  29. Content type: Research

    In patients with T4 nasopharyngeal carcinoma (NPC), death may occur prior to the occurrence of temporal lobe injury (TLI). Because such competing risk death precludes the occurrence of TLI and thus the competi...

    Authors: Juan Huang, Fang-fang Kong, Ronald Wihal Oei, Rui-ping Zhai, Chao-su Hu and Hong-mei Ying

    Citation: Radiation Oncology 2019 14:31

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  30. Content type: Research

    Intra-individual heterogeneity of cardiac exposure is an issue in breast cancer (BC) radiotherapy that was poorly considered in previous cardiotoxicity studies mainly based on mean heart dose (MHD). This dosim...

    Authors: Sophie Jacob, Jérémy Camilleri, Sylvie Derreumaux, Valentin Walker, Olivier Lairez, Mathieu Lapeyre, Eric Bruguière, Atul Pathak, Marie-Odile Bernier, Dominique Laurier, Jean Ferrieres, Olivier Gallocher, Igor Latorzeff, Baptiste Pinel, Denis Franck, Christian Chevelle…

    Citation: Radiation Oncology 2019 14:29

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  31. Content type: Review

    This systematic review aims to elucidate the diagnostic accuracy of radiological examinations to distinguish between brain radiation necrosis (BRN) and tumor progression (TP).

    Authors: Motomasa Furuse, Naosuke Nonoguchi, Kei Yamada, Tohru Shiga, Jean-Damien Combes, Naokado Ikeda, Shinji Kawabata, Toshihiko Kuroiwa and Shin-Ichi Miyatake

    Citation: Radiation Oncology 2019 14:28

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  32. Content type: Research

    The SCOPE trials (SCOPE 1, NeoSCOPE and SCOPE 2) have been the backbone of oesophageal RT trials in the UK. Many changes in oesophageal RT techniques have taken place in this time. The SCOPE trials have, in ad...

    Authors: S. Gwynne, E. Higgins, A. Poon King, G. Radhakrishna, L. Wills, S. Mukherjee, Maria Hawkins, G. Jones, J. Staffurth and T. Crosby

    Citation: Radiation Oncology 2019 14:26

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  33. Content type: Research

    Carbon ion radiotherapy (CIRT) has been delivered to more than 20,000 patients worldwide. International trials have been recommended in order to emphasize the actual benefits. The ULICE program (Union of Light...

    Authors: G. Vogin, A. Wambersie, M. Koto, T. Ohno, M. Uhl, P. Fossati and J. Balosso

    Citation: Radiation Oncology 2019 14:24

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  34. Content type: Research

    To compare WBC counts during treatment of localized prostate cancer with either conventionally fractionated (CF) or moderately hypofractionated (HYPO) radiotherapy.

    Authors: Giuseppe Sanguineti, Diana Giannarelli, Maria Grazia Petrongari, Stefano Arcangeli, Angelo Sangiovanni, Biancamaria Saracino, Alessia Farneti, Adriana Faiella, Mario Conte and Giorgio Arcangeli

    Citation: Radiation Oncology 2019 14:23

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  35. Content type: Research

    Three-dimensional ultrasound (3DUS) is an attractive option in image-guided radiotherapy (IGRT) for prostate cancer (PCa) patients. However, the potential factors influencing the accuracy of 3DUS in comparison...

    Authors: Sha Zhou, Liling Luo, Jibin Li, Maosheng Lin, Li Chen, Jianhui Shao, Shipei Lu, Yaru Ma, Yingting Zhang, Wenfen Chen, Mengzhong Liu, Shiliang Liu and Liru He

    Citation: Radiation Oncology 2019 14:22

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  36. Content type: Methodology

    Despite the advances in oncology, patients with bulky tumors have worse prognosis and often receive only palliative treatments. Bulky disease represents an important challenging obstacle for all currently avai...

    Authors: Slavisa Tubin, Helmut H. Popper and Luka Brcic

    Citation: Radiation Oncology 2019 14:21

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  37. Content type: Research

    This study aimed to evaluate the role of postoperative radiotherapy (RT) in dermatofibrosarcoma protuberans (DFSP) and identify the prognostic factors influencing the disease-free survival (DFS).

    Authors: Kaixin Du, Jinluan Li, Lirui Tang, Xiaoyi Lin, Xiangquan Kong, Xuehong Liao, Qingqin Peng, Yaping Dong, Junyan He, Yunxia Huang, Xueqing Zhang, Feifei Lin, Qingyang Zhuang and Junxin Wu

    Citation: Radiation Oncology 2019 14:20

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  38. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is associated with fatal complications after radiotherapy (RT) for lung cancer patients; however, the role of proton therapy to reduce the incidence of life-threatening comp...

    Authors: Hakyoung Kim, Hongryull Pyo, Jae Myoung Noh, Woojin Lee, Byoungsuk Park, Hye Yun Park and Hongseok Yoo

    Citation: Radiation Oncology 2019 14:19

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  39. Content type: Research

    Preclinical studies suggest enhanced anti-tumor activity with combined radioimmunotherapy. We hypothesized that radiation (RT) + immunotherapy would associate with improved overall survival (OS) compared to im...

    Authors: Corey C. Foster, David J. Sher, Chad G. Rusthoven, Vivek Verma, Michael T. Spiotto, Ralph R. Weichselbaum and Matthew Koshy

    Citation: Radiation Oncology 2019 14:18

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  40. Content type: Research

    Helical irradiation of the total skin (HITS) was modified as simultaneous integrated boost (SIB)-helical arc radiotherapy of total skin (HEARTS) technique and applied to an acute myeloid leukemia (AML) patient...

    Authors: Chen-Hsi Hsieh, Hui-Ju Tien, Yuan-Bin Yu, Yuan-Hung Wu, Pei-Wei Shueng, Yueh-Feng Lu, Shan-Ying Wang and Li-Ying Wang

    Citation: Radiation Oncology 2019 14:17

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  41. Content type: Research

    To evaluate the safety and efficacy of particle therapy (PT) using pencil beam scanning (PBS) technique for early stage non-small cell lung cancer (NSCLC).

    Authors: Jian Chen, Jiade J. Lu, Ningyi Ma, Jingfang Zhao, Chang Chen, Min Fan, Guoliang Jiang and Jingfang Mao

    Citation: Radiation Oncology 2019 14:16

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  42. Content type: Research

    We created a scoring system incorporating dosimetric and clinical factors to assess the risk of severe, acute skin reactions in patients undergoing intensity-modulated radiation therapy (IMRT) to treat head an...

    Authors: Mitsue Kawamura, Michio Yoshimura, Hiromi Asada, Mitsuhiro Nakamura, Yukinori Matsuo and Takashi Mizowaki

    Citation: Radiation Oncology 2019 14:14

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  43. Content type: Research

    The selection of radiation therapy dose fractionation schedules for bone metastases is often based on the estimation of life expectancy. Therefore, accurate prognosis prediction is an important issue. It is re...

    Authors: Hikaru Kubota, Toshinori Soejima, Nor Shazrina Sulaiman, Shuhei Sekii, Yoko Matsumoto, Yosuke Ota, Kayoko Tsujino, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Junichi Ikegaki, Koji Matsumoto and Ryohei Sasaki

    Citation: Radiation Oncology 2019 14:13

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  44. Content type: Research

    The aim of this study is to evaluate the prognostic value of grading MRI–detected skull-base invasion in nasopharyngeal carcinoma (NPC) with skull-base invasion after intensity-modulated radiotherapy (IMRT).

    Authors: Yanru Feng, Caineng Cao, Qiaoying Hu and Xiaozhong Chen

    Citation: Radiation Oncology 2019 14:10

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  45. Content type: Research

    Induction chemotherapy (IC) now is gaining recognition for the treatment of nasopharyngeal carcinoma (NPC). The current study was conducted to examine the association between prognosis and the interval between...

    Authors: Liang Peng, Jin-Qi Liu, Cheng Xu, Xiao-Dan Huang, Ling-Long Tang, Yu-Pei Chen, Ying Sun and Jun Ma

    Citation: Radiation Oncology 2019 14:9

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  46. Content type: Research

    The optimal care for pT3N0 rectal cancer remains controversial. And whether tumor location can be used to guide the administration of adjuvant radiotherapy for pT3N0 rectal cancer is not fully confirmed. The c...

    Authors: Hai-hua Peng, Xin-hui Zhou, Tong-chong Zhou, Xing-sheng Qiu and Kai-yun You

    Citation: Radiation Oncology 2019 14:8

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  47. Content type: Research

    Lung dose-volume histogram (DVH) in radiotherapy could be calculated from multiple normal lung definitions. The lung dosimetric parameters generated from various approaches are significantly different. However...

    Authors: Yinnan Meng, Haihua Yang, Wei Wang, Xingni Tang, Caiping Jiang, Yichao Shen and Wei Luo

    Citation: Radiation Oncology 2019 14:7

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  48. Content type: Research

    We performed a prospective phase II study to compare acute toxicity among five different hypofractionated schedules using proton therapy. This study was an exploratory analysis to investigate the secondary end...

    Authors: Boram Ha, Kwan Ho Cho, Kang Hyun Lee, Jae Young Joung, Yeon-Joo Kim, Sung Uk Lee, Hyunjung Kim, Yang-Gun Suh, Sung Ho Moon, Young Kyung Lim, Jong Hwi Jeong, Haksoo Kim, Weon Seo Park and Sun Ho Kim

    Citation: Radiation Oncology 2019 14:4

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  49. Content type: Study protocol

    This study was conducted to investigate a new short-course radiotherapy regimen for patients with metastatic hormone refractory prostate cancer (HRPC) presenting with a dominant debilitating symptom.

    Authors: Jesper Carl, Dirk Rades, Claudia Doemer, Cornelia Setter, Jürgen Dunst and Niels Henrik Holländer

    Citation: Radiation Oncology 2019 14:3

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