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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Content type: Research

    While intensity modulated radiotherapy (IMRT) has been widely adopted for the treatment of anal cancer (AC), the added contour complexity poses potential risks. This study investigates the impact of contour va...

    Authors: Michael P. Jones, Jarad Martin, Kerwyn Foo, Patrick Estoesta, Lois Holloway and Michael Jameson

    Citation: Radiation Oncology 2018 13:97

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  2. Content type: Research

    IMRT provides higher dose conformation to the target and dose sparing to surrounding tissues than 3DCRT. Monte Carlo method in Medical Physics is not a novelty to approach dosimetric problems. A new PENELOPE b...

    Authors: Alessandro Esposito, Sofia Silva, Jorge Oliveira, Joana Lencart and João Santos

    Citation: Radiation Oncology 2018 13:91

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  3. Content type: Review

    68Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative i....

    Authors: Sebastian Zschaeck, Fabian Lohaus, Marcus Beck, Gregor Habl, Stephanie Kroeze, Constantinos Zamboglou, Stefan Alexander Koerber, Jürgen Debus, Tobias Hölscher, Peter Wust, Ute Ganswindt, Alexander D. J. Baur, Klaus Zöphel, Nikola Cihoric, Matthias Guckenberger, Stephanie E. Combs…

    Citation: Radiation Oncology 2018 13:90

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  4. Content type: Research

    With the advance of modern irradiation techniques, the role of radiotherapy (RT) for intracranial meningioma has increased significantly throughout the past years. Despite that tumor’s generally favorable outc...

    Authors: Rami A. El Shafie, Maja Czech, Kerstin A. Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus and Stephanie E. Combs

    Citation: Radiation Oncology 2018 13:86

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  5. Content type: Research

    L’Hermitte’s sign (LS) after chemoradiotherapy for head and neck cancer appears related to higher spinal cord doses. IMRT plans limit spinal cord dose, but the incidence of LS remains high.

    Authors: Hannah M. Laidley, David J. Noble, Gill C. Barnett, Julia R. Forman, Amy M. Bates, Richard J. Benson, Sarah J. Jefferies, Rajesh Jena and Neil G. Burnet

    Citation: Radiation Oncology 2018 13:84

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  6. Content type: Research

    Previous studies reported that patients with preexisting radiological interstitial lung abnormalities (ILAs) were more susceptible to developing radiation pneumonitis (RP) after thoracic radiation therapy (TRT...

    Authors: Fangjuan Li, Ziyang Zhou, Ailu Wu, Yong Cai, Hongyu Wu, Ming Chen and Shixiong Liang

    Citation: Radiation Oncology 2018 13:82

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  7. Content type: Research

    SBRT is standard therapy for early stage lung cancer. Toxicity in central tumors has been a concern. RTOG 0813 showed that central SBRT is safe and effective. We report our experience with central SBRT.

    Authors: Yasmin Korzets ceder, Eyal Fenig, Aron Popvtzer, Nir Peled, Mordechai R. Kramer, Milton Saute, Dima Bragilovsky, Tzippy Schochat and Aaron M. Allen

    Citation: Radiation Oncology 2018 13:77

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  8. Content type: Research

    Oligo-recurrence has been considered to confer improved prognosis than other oligometastatic conditions, and stereotactic body radiation therapy (SBRT) is considered as an option of local therapy for lung or l...

    Authors: Masaki Nakamura, Naoki Hashimoto, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Ryo Nishikawa, Yoshiro Matsuo, Hiroki Kawaguchi and Hideki Nishimura

    Citation: Radiation Oncology 2018 13:75

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  9. Content type: Research

    The aim of this prospective clinical quality assessment was to evaluate the short-term and long-term efficacy of low dose radiotherapy (RT) for calcaneodynia, achillodynia, painful gonarthrosis, painful bursit...

    Authors: Oliver Micke, Eyup Ugrak, Stefan Bartmann, Irenaeus A. Adamietz, Ulrich Schaefer, Rebecca Bueker, Klaus Kisters, M. Heinrich Seegenschmiedt, Khashayar Fakhrian and Ralph Muecke

    Citation: Radiation Oncology 2018 13:71

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  10. Content type: Research

    Thoracic reirradiation (re-RT) is increasingly administered. However, radiation pneumonitis (RP) remains to be the most common side effect from retreatment. This study aimed to determine the risk and predictor...

    Authors: Chengbo Ren, Tianlong Ji, Tingting Liu, Jun Dang and Guang Li

    Citation: Radiation Oncology 2018 13:69

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  11. Content type: Case report

    Total skin electron beam therapy (TSEBT) is an effective treatment in mycosis fungoides. Total skin helical tomotherapy (TSHT) may be an alternative to TSEBT and may offer several dosimetric and treatment adva...

    Authors: Eric M. Schaff, Stephen A. Rosenberg, Stephanie J. Olson, Steven P. Howard and Kristin A. Bradley

    Citation: Radiation Oncology 2018 13:67

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  12. Content type: Research

    We hypothesized that dominant intraprostatic lesions (DILs) could be depictured by multimodal imaging techniques (MRI and/or PSMA PET/CT) in patients with primary prostate cancer (PCa) and investigated possibl...

    Authors: Constantinos Zamboglou, Christina Marie Klein, Benedikt Thomann, Thomas Franz Fassbender, Hans C. Rischke, Simon Kirste, Karl Henne, Natalja Volegova-Neher, Michael Bock, Mathias Langer, Philipp T. Meyer, Dimos Baltas and Anca L. Grosu

    Citation: Radiation Oncology 2018 13:65

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  13. Content type: Research

    To determine if reduced dose delivery uncertainty is associated with daily image-guidance (IG) and Prostate Specific Antigen Relapse Free Survival (PRFS) in intensity-modulated radiotherapy (IMRT) of high-risk...

    Authors: Per Munck af Rosenschold, Michael J. Zelefsky, Aditya P. Apte, Andrew Jackson, Jung Hun Oh, Elliot Shulman, Neil Desai, Margie Hunt, Pirus Ghadjar, Ellen Yorke and Joseph O. Deasy

    Citation: Radiation Oncology 2018 13:64

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  14. Content type: Research

    Lung stereotactic ablative radiotherapy (SABR) is associated with low morbidity, however there is an increased risk of treatment-related toxicity in tumors directly abutting or invading the proximal bronchial ...

    Authors: Donna H. Murrell, Joanna M. Laba, Abigail Erickson, Barbara Millman, David A. Palma and Alexander V. Louie

    Citation: Radiation Oncology 2018 13:57

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  15. Content type: Research

    Meningiomas of the skull base account for 25–30% of all meningiomas. Due to the complex structure of the cranial base and its close proximity to critical structures, surgery is often associated with substantia...

    Authors: Rami A. El Shafie, Maja Czech, Kerstin A. Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus and Stephanie E. Combs

    Citation: Radiation Oncology 2018 13:54

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  16. Content type: Research

    68Ga-PSMA-PET-imaging has proven to be a highly sensitive and specific diagnostic element for patients with prostate cancer (PC). Does the standard clinical target volume (CTV) cover the majority of 68Ga-PSMA-PET...

    Authors: K. Schiller, M. Devecka, T. Maurer, M. Eiber, J. Gschwend, M. Schwaiger, S. E. Combs and G. Habl

    Citation: Radiation Oncology 2018 13:36

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  17. Content type: Study protocol

    Concurrent chemoradiotherapy is a standard modality for locally advanced esophageal squamous cell carcinoma (ESCC) patients. Cisplatin combined with 5-fluorouracil continuous infusion (PF) remains the standard...

    Authors: Yun Chen, Zhengfei Zhu, Weixin Zhao, Ling Li, Jinjun Ye, Chaoyang Wu, Huarong Tang, Qin Lin, Jiancheng Li, Yi Xia, Yunhai Li, Jialiang Zhou and Kuaile Zhao

    Citation: Radiation Oncology 2018 13:33

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  18. Content type: Research

    The purpose of this study was to evaluate the prognostic impact of Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) and Response Evaluation Criteria in Solid Tumors (RECIST) and of pre-...

    Authors: Cory Pierson, Taras Grinchak, Casey Sokolovic, Brandi Holland, Teresa Parent, Mark Bowling, Hyder Arastu, Paul Walker and Andrew Ju

    Citation: Radiation Oncology 2018 13:34

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