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Table 3 The subgroup analysis of the bone density (HU = Hounsfield units) in metastatic bone before RT (baseline), as well as 3 and 6 months after RT

From: Bone density and pain response following intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for vertebral metastases - secondary results of a randomized trial

  IMRT group   3DCRT group   Differences between groups  
n Median SD n Median SD HL 95% CI p-value
Mixed
 HU Baseline 17 242.0 100.1 10 230.5 77.3 −41.5 − 128.0-40.0 0.238
 HU T2 11 360.0 153.1 5 418.0 89.4 58.0 − 114-204.0 0.450
 HU T3 9 355.0 174.1 4 559.5 132.0 190.5 −61.0-416.0 0.190
3 months
 HU T0-T2 11 102.0 92.2 5 164.0 68.4 59.0 −43.0-174.0 0.213
 HU T0-T2 (%) 11 38.8 41.2 5 60.8 48.5 25.7 −32.5-89.5 0.256
6 months
 HU T0-T3 9 176.0 123.1 4 301.0 89.4 161.5 73.0–341.0 0.025
 HU T0-T3 (%) 9 55.0 61.1 4 145.9 42.2 80.7 8.7–155.1 0.037
Osteolytic
 HU Baseline 6 178.5 74.3 14 156.5 60.9 20.0 −60.0 − 82.0 0.536
 HU T2 4 269.5 198.4 8 181.5 70.8 84.0 -82.0-387.0 0.270
 HU T3 4 153.0 127.7 3 295.0 82.8 126.5 − 184.0-277.0 0.377
3 months
 HU T0-T2 4 35.5 171.2 8 16.0 38.0 19.5 −53.0-364.0 0.489
 HU T0-T2 (%) 4 20.3 83.11 8 9.3 21.2 12.2 −27.5-178.4 0.489
6 months
 HU T0-T3 4 10.0 95.3 3 64.0 89.1 110.0 −60.0-315.0 0.212
 HU T0-T3 (%) 4 −0.8 55.4 3 27.7 55.0 46.9 −61.2-174.2 0.377
Osteoblastic
 HU Baseline 7 419.0 247.6 6 426.0 159.8 −94.5 − 415.0-172.0 0.520
 HU T2 5 574.0 327.0 6 481.5 174.4 145.5 − 284.0-604.0 0.411
 HU T3 5 700.0 374.8 5 475.0 196.4 255.0 − 367.0-711.0 0.296
3 months
 HU T0-T2 5 52.0 188.3 6 13.0 103.3 45.0 − 311.0-155.0 0.647
 HU T0-T2 (%) 5 15.4 35.8 6 3.1 27.5 3.0 −57.0-30.8 1.000
6 months
 HU T0-T3 5 130.0 241.7 5 57.0 102.9 42.0 − 408.0-224.0 0.676
 HU T0-T3 (%) 5 15.4 47.2 5 13.6 27.3 1.7 −77.9-53.4 1.000
  1. The results were presented by absolute and relative values (%) of HU within and between groups as median (Hodges–Lehmann estimate) and IQR. Abbreviations: HU Hounsfield units, IQR interquartile range, T0 baseline, T2 3 months, T3 6 months, T0–T2 difference in baseline minus 3 months, T0-T3 difference in baseline minus 6 months