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Table 4 Comparison of dose to organs at risk for 4 planning treatment: PTV66, PTV FDG 70%, PTV F-miso, PTV FDG 42 Gy

From: FDG and FMISO PET-guided dose escalation with intensity-modulated radiotherapy in lung cancer

Scenario Boost target volume Dose-volume constraint to organ at risk
Mean lung dose (Gy) D2% spinal cord (Gy) V35 heart (%) V50 oesophagus (%)
Reference plan   11.5 (±0.5) 32.7 (±2.1) 5** (±1.7) 20.5 (±2.7)
Scenario 2 FDG Hotspot 11.7 (±0.5) 32 (±2.1) 5.3 (±1.8) 20.4 (±2.6)
Scenario 3 Fmiso 11.8 (±0.5) 31.6 (±2.1) 5.2 (±1.9) 21 (±2.6)
Scenario 4 FDG per treatment 13.4 (±1.5) 32.2 (±2.3) 5.4** (±1.8) 20.8 (±2.7)
p value   0.2 0.7 0.03 0.4
  1. **significant difference