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Table 3 Comparison of dose to CTV or BTV for 4 planning treatment: CTV66, BTV FDG 70%, BTV F-miso, BTV FDG 42 Gy

From: FDG and FMISO PET-guided dose escalation with intensity-modulated radiotherapy in lung cancer

Scenario Boost target volume Mean (± SE) doses to target volumes (Gy)  
CTV66 BTV FDG 70% BTV FMISO BTV FDG 42Gy p value
Reference plan (66 Gy)   65.1 (± 0.35) 67.1 (± 0.32) 66.9 (± 0.38) 66.8 (± 0.39) NA
Scenario 2 18FDG Hotspot 65.9 (± 0.47) 74.3 (± 0.32) 70.4 (± 0.86) 70.4 (± 0.88) 0.001
Scenario 3 18F-miso 65.9 (± 0.53) 72.6 (± 0.86) 74.6 (± 0.33) 71.7 (± 0.9) 0.001
Scenario 4 18FDG per RT 66.8 (± 0.42) 73.5 (± 0.68) 72.5 (± 0.7) 74.6 (± 0.31) 0.001
  1. Data in boldface is the reference dose by plan