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Table 5 Risk analysis for different organs and endpoints for manual and automated plans

From: Auto- versus human-driven plan in mediastinal Hodgkin lymphoma radiation treatment

Structure Clinical endpoint Reference Median (range) p-value< 0.05d
Manual-BF Pinnacle3Auto-Planning
1 AP-BF AP-ARC 1vs.2, 3 2vs.3
2 3
    NTCP (%)
Heart Valvular defects Cella et al. (2013) 26.71 (0.96–82.63) 21.14 (0.96–84.21) 16.09 (0.94–81.36)
Lungs Radiation fibrosisa Cella et al. (2015)b 5.85 (2.72–8.39) 6.41 (2.19–8.03) 5.53 (1.30–7.51) 1 < 2 2 > 3
Cella et al. (2015)c 6.05 (3.33–16.79) 3.88 (3.21–7.87) 4.80 (3.22–7.94) 1 > 2,3 2 < 3
Thyroid Hypothyroidism Cella et al. (2012) 3.22 (2.08–9.98) 3.16 (2.15–4.36) 2.62 (1.78–3.58)
    RRR
Heart Major coronary events van Nimwegen et al. (2015) 1.28 (1.01–1.64) 1.24 (1.01–1.53) 1.22 (1.01–1.47) 1 > 2,3 2 > 3
    OR   
LAD Coronary stenosis Moignier et al. (2015) 1.06 (1.00–3.43) 1.04 (1.00–1.77) 1.05 (1.00–1.93) 1 > 2  
  1. Abbreviations: LAD Left Anterior Descending artery, NTCP Normal Tissue Complication Probability, RRR Relative Risk Ratio, OR Odds Ratio
  2. aComputed assuming an age of 30 years at time of irradiation; bModel including lungs D2%; cModel including left lung V5Gy; dFriedman and Dunn test