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Table 4 Dosimetric indices and comparative analysis for Planning Target Volume (PTV) and different organs at risk for manual and automated plans

From: Auto- versus human-driven plan in mediastinal Hodgkin lymphoma radiation treatment

Structure Dose Index Median (range) p-value< 0.05a
Manual-BF Pinnacle3Auto-Planning
1 AP-BF AP-ARC 1vs.2,3 2vs.3
2 3
PTV HI 0.12 (0.09–0.16) 0.16 (0.1–0.22) 0.13 (0.09–0.18) 1 < 2 2 > 3
CI 0.95 (0.94–0.96) 0.95 (0.94–0.95) 0.95 (0.95–0.97)
Heart Dmean (Gy) 3.8 (0.2–8.7) 3.3 (0.2–7.2) 3 (0.1–6.3) 1 > 2,3 2 > 3
D2% (Gy) 28.4 (0.4–31.5) 28.3 (0.4–31.3) 26.8 (0.3–30.2) 1 > 3 2 > 3
Left Ventricle Dmean (Gy) 1 (0.1–3.1) 0.7 (0.1–1.6) 0.8 (0.1–1.7) 1 > 2,3
LAD D50% (Gy) 1.3 (0.0–25.7) 0.8 (0.0–11.9) 1 (0.0–13.7) 1 > 2
Lungs Dmean (Gy) 6.3 (1.6–9.2) 4.5 (1.4–5.9) 4.6 (1.4–6.0) 1 > 2,3
V5Gy (%) 32.0 (7.5–52.4) 20.9 (6.3–29.0) 23.7 (7.7–35.0) 1 > 2 2 < 3
V20Gy (%) 11.6 (2.6–18.5) 8.4 (2.0–12.3) 7.2 (1.0–9.7) 1 > 3 2 > 3
Thyroid Dmean (Gy) 16.8 (11.9–28.4) 15.4 (10.1–25.7) 15.5 (9.6–21.2) 1 > 2,3
V30Gy (%) 19.6 (7.9–51.3) 19.2 (8.7–27.9) 14.0 (3.7–22.5)
Breast Dmean (Gy) 1.1 (0.1–2.3) 0.4 (0.1–1.2) 0.6 (0.1–1.6) 1 > 2,3 2 < 3
Normal Tissue Dmean (Gy) 2.9 (1.5–5.4) 2.4 (1.4–3.8) 2.4 (1.2–3.7) 1 > 2  
  1. Abbreviations: PTV planning Target Volume, HI Homogeneity Index, Conformity Index, Dmean mean dose, D2% near maximum dose, D50% median dose, VX percentage volume exceeding X, LAD Left Anterior Descending artery
  2. aFriedman and Dunn tests