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Table 5 Survival outcomes of submandibular gland carcinoma patients bearing adverse pathological risk factors, treatment with or without postoperative bilateral elective nodal irradiation

From: Nodal failure patterns and utility of elective nodal irradiation in submandibular gland carcinoma treated with postoperative radiotherapy - a multicenter experience

Variable   RC (%) DMFS (%) DFS (%) OS (%)
N 5-y 10-y P 5-y 10-y P 5-y 10-y P 5-y 10-y P
Entire cohort
 Extended ENI 18 90.0 90.0 0.207 59.3 59.3 0.700 59.3 59.3 0.871 70.3 61.6 0.636
 Limited ENI 47 76.6 76.6   67.6 67.6   65.4 65.4   72.3 63.6  
pN+
 Extended ENI 9 100 100 0.003 51.9 51.9 0.166 51.9 51.9 0.034 44.4 44.4 0.333
 Limited ENI 9 0   12.5   0   27.8 0  
Extranodal extension
 Extended ENI 6 100 100 0.022 44.4 44.4 0.328 44.4 44.4 0.161 50.0 50.0 0.319
 Limited ENI 6 20.0   0   0   0  
pT3–4
 Extended ENI 8 100 100 0.044 40.0 40.0 0.694 40.0 40.0 0.579 37.5 18.8 0.288
 Limited ENI 18 41.0 41.0   32.7 32.7   34.3 34.3   49.1 32.8  
Lymphovascular invasion
 Extended ENI 9 80.0 80.0 0.014 32.4 32.4 0.472 32.4 32.4 0.351 55.6 44.4 0.392
 Limited ENI 9 25.0 25.0   25.0 25.0   25.0 25.0   33.3 22.2  
Perineural invasion
 Extended ENI 9 80.0 0.353 25.9 0.195 25.9 0.300 55.6 41.7 0.270
 Limited ENI 26 66.3 66.3   57.0 57.0   52.6 52.6   69.4 52.9  
Margin < 1 mm
 Extended ENI 12 83.3 83.3 0.512 61.1 61.1 0.905 61.1 61.1 0.763 71.4 53.6 0.374
 Limited ENI 35 78.0 78.0   70.3 70.3   66.8 66.8   77.1 65.4  
High grade histology
 Extended ENI 41 88.9 88.9 0.179 63.3 63.3 0.899 63.3 63.3 0.650 68.4 58.6 0.721
 Limited ENI 17 73.1 73.1   63.0 63.0   60.4 60.4   68.6 58.8  
0 risk factora
 Extended ENI 6 100 100 100 100 0.533 100 100 0.533 100 100 0.449
 Limited ENI 26 100 100   91.1 91.1   91.1 91.1   87.9 87.9  
≥1 risk factora
 Extended ENI 12 85.7 85.7 0.039 43.2 43.2 0.558 43.2 43.2 0.349 58.3 48.6 0.752
 Limited ENI 21 45.1 45.1   38.2 38.2   31.5 31.5   52.4 32.7  
≥2 risk factorsa
 Extended ENI 11 83.3 83.3 < 0.001 36.8 36.8 0.019 36.8 36.8 0.007 54.5 43.6 0.117
 Limited ENI 8 14.3   0 0   0 0   16.7 0  
  1. Abbreviations: DFS disease free survival, DMFS distant metastasis free survival, ENI elective nodal irradiation, OS overall survival, RC regional control
  2. aRisk factors: pN+, extranodal extension, pT3–4, and lymphovascular invasion