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Table 4 Univariate and multivariate analyses of clinicopathological risk factors for neck failure

From: Nodal failure patterns and utility of elective nodal irradiation in submandibular gland carcinoma treated with postoperative radiotherapy - a multicenter experience

Variables Ipsilateral neck failure Contralateral neck failure
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR 95% CI P HR 95% CI P HR 95% CI P HR 95% CI P
 N stage (pN+ vs pN0 & cN0/pNxa) 4.491 0.888–22.717 0.069 NS 5.305 1.176–23.925 0.030 NS
 Extranodal extension (Yes vs No) 1.607 0.185–13.984 0.667 NS 11.479 2.519–52.305 0.002 6.018 1.203–30.104 0.029
 T stage (pT3–4 vs pT1–2) 5.102 0.903–28.819 0.065 NS 12.293 1.472–102.668 0.021 NS
 Lymphovascular invasion (Yes vs No) 3.738 0.751–18.597 0.107 NS 22.007 2.643–183.267 0.004 14.920 1.694–131.385 0.015
 Perineural invasion (Yes vs No) 63.645 0.089–45,483 0.215 NS 5.274 0.635–43.827 0.124 NS
 Margin (< 1 mm vs ≥ 1 mm) 1.860 0.217–15.951 0.571 NS 0.441 0.099–1.974 0.285 NS
 High-grade histology (Yes vs No) 24.834 0.001–872,589 0.548 NS 24.431 0.001–526,351.9 0.530 NS
 Ipsi. elective neck dissection (Yes vs No) 0.039 0.000–876.767 0.526 NS
 Ipsi. elective nodal irradiation (Yes vs No) 0.402 0.073–2.203 0.294 NS
 Cont. elective nodal irradiation (Yes vs No) 0.778 0.151–4.013 0.764 NS
  1. Abbreviations: CI confidence interval, Cont. contralateral, HR hazard ratio, Ipsi. ipsilateral, NS not statistically significant
  2. a, no elective neck dissection in cN0 patients