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Table 3 Univariate and multivariate analyses of adverse pathological factors

From: Nodal failure patterns and utility of elective nodal irradiation in submandibular gland carcinoma treated with postoperative radiotherapy - a multicenter experience

Univariate analysis   RC (%) LC (%) DMFS (%) DFS (%) OS (%)
Variable N 5-year P 5-year P 5-year P 5-year P 5-year P
N stage
 pN+ 18 49.6 0.002 75.0 0.015 31.1 < 0.001 24.5 < 0.001 37.5 < 0.001
 pN0 & cN0/pNxa 47 87.7   100   77.5   77.8   85.2  
Extranodal extension
 Yes 12 55.4 0.004 83.3 0.149 21.2 < 0.001 21.8 < 0.001 30.0 < 0.001
 No 53 84.2   97.3   74.2   72.0   81.0  
T stage
 pT3–4 26 57.9 < 0.001 93.8 0.104 33.2 < 0.001 35.1 < 0.001 45.9 < 0.001
 pT1–2 39 93.1   96.7   85.5   82.2   88.9  
Lymphovascular invasion
 Yes 15 51.0 < 0.001 90.0 0.569 29.6 < 0.001 30.5 < 0.001 44.4 < 0.001
 No 50 89.4   96.9   78.6   75.0   82.7  
Perineural invasion
 Yes 35 66.2 0.007 92.0 0.084 48.9 0.002 45.7 0.001 66.3 0.092
 No 30 95.7   100   87.9   87.9   78.0  
Margin < 1 mm
 Yes 47 79.1 0.910 96.6 0.794 68.7 0.418 66.0 0.449 75.7 0.475
 No 18 80.9   91.7   57.0   57.5   61.1  
High-grade histology
 Yes 59 77.1 0.204 94.9 0.466 63.0 0.324 61.3 0.287 68.4 0.079
 No 6 100   100   85.7   85.7   100  
Multivariate analysis
Variable HR 95% CI P Variable HR 95% CI P
Regional control Disease-free survival
 T stage (pT3–4 vs pT1–2) 8.129 1.661–39.779 0.010  N stage (pN+ vs pN0 & cN0/pNxa) 4.026 1.464–11.075 0.007
 Lymphovascular invasion (Yes vs No) 4.130 1.165–14.643 0.028  Perineural invasion (Yes vs No) 5.377 1.512–19.121 0.009
Local control NS  T stage (pT3–4 vs pT1–2) 3.762 1.262–11.213 0.017
Distant metastasis-free survival Overall survival
 T stage (pT3–4 vs pT1–2) 5.171 1.715–15.591 0.004  N stage (pN+ vs pN0 & cN0/pNxa) 4.363 1.710–11.127 0.002
 Perineural invasion (Yes vs No) 4.337 1.234–15.236 0.022  T stage (pT3–4 vs pT1–2) 4.841 1.671–14.020 0.004
 Lymphovascular invasion (Yes vs No) 2.719 1.065–6.942 0.037     
  1. Abbreviations: CI confidence interval, DFS disease free survival, DMFS distant metastasis free survival, HR Hazard ratio, LC local control, NS not statistically significant, OS overall survival, RC regional control
  2. a,no elective neck dissection in cN0 patients