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Table 1 Patient characteristics

From: Nodal failure patterns and utility of elective nodal irradiation in submandibular gland carcinoma treated with postoperative radiotherapy - a multicenter experience

Characteristic N %
Sex
 Female/Male 35/30 54/46
Age (years)
 Median (range) 53 (24–79)
Performance score
 ECOG 0–1 65 100
T stage
 pT1 15 23
 pT2 24 37
 pT3 20 31
 pT4a 6 9
Tumor size (cm)
 Median (range) 2.9 (0.5–8.0)
N stage
 pN0 6 9
 pN1 3 5
 pN2b 15 23
 cN0/pNxa 41 63
Disease stage
 I 13 20
 II 22 34
 III 11 17
 IVa 19 29
Staging modality
 CT 49 75
 MRI 6 9
18F-FDG-PET 23 35
Surgical margin
 < 1 mm/≥1 mm 46/19 71/29
Histology
 Adenoid cystic carcinoma 29 45
 Carcinoma ex pleomorphic adenoma 11 17
 Mucoepidermoid carcinoma 8 12
 Lymphoepithelial carcinoma 6 9
 Squamous cell carcinoma 4 6
 Salivary duct carcinoma 4 6
 Adenocarcinoma 2 3
 Myoepithelial carcinoma 1 2
Histology grading
 Low to intermediate/High 6/59 9/91
Pathological features
 Perineural invasion 35 54
 Extranodal extension 12 19
 Bone invasion 2 3
 Skin invasion 1 2
 Lymphovascular invasion 18 28
Neck dissection
 None 41 63
 Ipsilateral elective 9 14
 Ipsilateral therapeutic 15 23
 Contralateral 0 0
 < 18 nodes 22 34
 ≥18 nodes 17 26
Nodal irradiation
 Extended ENI 18 28
 Limited ENI 47 72
Concurrent chemotherapy 24 37
 Radiotherapy technique
  3D-CRT 19 29
  IMRT 31 48
  VMAT 15 23
Radiotherapy dose (Gy)
 Median (range) 66 (32–72)
  1. Abbreviations: 3D-CRT three-dimensional conformal radiotherapy, CT computed tomography, ECOG Eastern Cooperative Oncology Group, ENI elective nodal irradiation, 18F-FDG-PET 18F-fluorodeoxyglucose positron emission tomography, IMRT intensity-modulated radiation therapy, MRI magnetic resonance imaging, VMAT volumetric modulated arc therapy
  2. a,no elective neck dissection in cN0 patients