You are viewing the site in preview mode

Skip to main content

Advertisement

Table 2 Gene expression analysis by qRT-PCR in an independent subset of 42 LABC tumor samples

From: Molecular signature of response to preoperative radiotherapy in locally advanced breast cancer

# Gene Symbol Amplicon Length Responders (R)(n = 30) Non-responders (NR)(n = 12) p-value Fold change
mean sd mean sd
1 APOA1 63 5.99 1.96 7.55 1.37 0.0161** 0.34
2 CHEK2 109 −4.63 1.69 −4.18 1.06 0.390 0.73
3 IDO1 106 1.06 2.87 0.63 2.82 0.662 1.35
4 MAP3K4 89 −3.00 1.99 −1.78 1.28 0.0582* 0.43
5 MCM6 109 −5.12 1.98 −4.88 2.34 0.741 0.85
6 MMP14 92 7.85 2.85 9.61 2.03 0.0596* 0.30
7 ST3GAL4 60 −3.95 2.68 −3.38 3.32 0.566 0.67
8 WHSC1L1 67 −0.98 3.90 −1.16 4.61 0.979 1.13
9 XRCC2 66 −4.68 2.08 −4.04 2.13 0.455 0.64
  1. Gene expression was determined by qRT-PCR in independent test set of 60 FFPE breast tumors, of wich 42 were retained for data anlysis. Represented data were interplate calibrated, normalized to B-Actin and log2 transformed. Normality was evaluated using Lilform test. p-values - level of significance according to the Student’s t-test or nonparametric Kolmogorov-Smirnov test (WHSC1L1 and ST3GAL4), FC fold change gene expression relative to ACTB between pRT responders (R) to nonresponders (NR) tumors measured by qPR-PCR; Fold change is shown on a linear scale
  2. *p-value < 0.1; **p-value < 0.05