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Table 3 Summary of radiation brain stem injury tolerance expressed using ROC curve

From: A retrospective dosimetry study of intensity-modulated radiotherapy for nasopharyngeal carcinoma: radiation-induced brainstem injury and dose-volume analysis

Factor Area under ROC curve β p value Lower limit Upper limit Cutoff point sensitivity specificity
GTVnx D2% 0.724 0.078 0.030 0.571 0.878 77.26 0.875 0.614
Dmax 0.813 0.067 0.002 0.682 0.945 67.85 0.750 0.859
D1% 0.818 0.068 0.002 0.685 0.952 60.75 0.875 0.803
D 0.1cc 0.818 0.064 0.002 0.692 0.944 60.76 0.875 0.752
D 1cc 0.798 0.069 0.004 0.663 0.932 54.58 0.875 0.737
  1. D2% near the maximum absorbed dose of GTVnx, Dmax the maximum point dose of brainstem, D1% the dose of 1% brainstem volume, D0.1cc the maximum dose of brainstem delivered to a volume of 0.1 ml, D1cc the maximum dose of brainstem delivered to a volume of 1.0 ml, GTVnx Gross tumor volume of nasopharyngeal primary lesions and their direct extensions
  2. Abbreviation: ROC Receiver operating characteristic, GTV Gross tumor volume