- Open Access
Finer leaf resolution and steeper beam edges using a virtual isocentre in concurrence to PTV-shaped collimators in standard distance – a planning study
© The Author(s). 2017
- Received: 13 March 2017
- Accepted: 16 May 2017
- Published: 25 May 2017
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Investigation of a reduced source to target distance to improve organ at risk sparing during stereotactic irradiation (STX).
The authors present a planning study with perfectly target-volume adapted collimator compared with multi-leaf collimator (MLC) at reduced source to virtual isocentre distance (SVID) in contrast to normal source to isocentre distance (SID) for stereotactic applications. The role of MLC leaf width and 20–80% penumbra was examined concerning the healthy tissue sparing. Several prescription schemes and target diameters are considered.
Paddick’s gradient index (GI) as well as comparison of the mean doses to spherical shells at several distances to the target is evaluated. Both emphasize the same results: the healthy tissue sparing in the high dose area around the planning target volume (PTV) is improved at reduced SVID ≤ 70 cm. The effect can be attributed more to steeper penumbra than to finer leaf resolution. Comparing circular collimators at different SVID just as MLC-shaped collimators, always the GI was reduced. Even MLC-shaped collimator at SVID 70 cm had better healthy tissue sparing than an optimal shaped circular collimator at SID 100 cm.
Regarding penumbra changes due to varying SVID, the results of the planning study are underlined by film dosimetry measurements with Agility™ MLC.
Penumbra requires more attention in comparing studies, especially studies using different planning systems. Reduced SVID probably allows usage of conventional MLC for STX-like irradiations.
- Stereotactic Irradiation
- Robotic table motion
- Multi-leaf collimator
- Planning study
- Virtual isocentre
Normal linacs are not considered to be suitable for modern stereotactic irradiation (STX). The main reason is the isocentric leaf width of common multi-leaf collimators (MLC). Typical isocentric 0.5 cm MLCs are assumed too coarse for STX. Leaf widths of the order of 0.3 cm are recommended by Bortfeld et al. . However, this value is subject to the typical 20–80% penumbra width of 0.25 cm to 0.3 cm. Since then, several authors more often consider MLC types and leaf widths [2–7], whereas other parameters which determine the dose gradient, such as the penumbra, are rarely examined or even varied. For example, the authors refer the reader to the method of penumbra control using intermediate energy photons  proposed by O’Malley et al.  or small-field flattening filters proposed by S.J. Thomas  in an older work,.
The purpose of the present work is to investigate whether a reduced source to target distance combined with MLC (0.5 cm isocentric leaf width) can compete against reference source to isocentre distance (SID) 100 cm combined with an ideal round collimator (a limit of infinitely narrow leaves). The circular collimator is the ideal shape for spherical targets only. The reduced source to target distance can be realized using, e. g., a virtual isocentre approach (Bratengeier K, Holubyev K, Wegener S: Distance-dependent penumbra: Theoretical considerations and practical implications for stereotactic irradiation using a MLC, submitted): Table positions are a function of the gantry angle and the isocentric table angle in a way that a selected target point is always hit by the beam central axis in a certain fixed distance from the source. This point behaves like an isocentre and is therefore called “virtual isocentre”. Its distance from the source is called source to virtual isocentre distance (SVID) which is allowed to differ from SID 100 cm. The apparatus as a whole behaves like a linac with changed SID, but however, the radiation head remains unchanged. For the present study we consider the SVID reduced to 70 cm, which is a reasonable distance for head applications, and a SVID of 50 cm to demonstrate the trends at further reduced SVID. Our special interest is to examine the role of reduced MLC leaf width separately from penumbra effects regarding improved healthy tissue sparing at reduced SVID.
Planning system and target definition
The planning study was performed by means of the therapy planning system (TPS) Philips Pinnacle3™ version 9.10. A virtual sphere of diameter 20 cm and physical density 1.0 g/cm3 was created in TPS on a 0.1 cm sliced CT. The spherical planning target volume (PTV) was placed in the centre. PTV of diameters (∅) of 1.0 cm, 1.3 cm and 1.7 cm were created inflating a nearly point size central object using Pinnacle3™ expansion functions. Using three different target diameters was intended to investigate the effect of different curvatures. The diameters were chosen small to recognize the effects of MLC induced grating.
Mean dose to spherical shells
To ensure technique-independent characterisation of the dose distribution, concentric spherical shells with borders at 0.3, 0.7, 1.0, 1.3, 1.6, 1.9, 2.2, 2.5, 2.8, 3.0, 4.0, 6.0 10.0 and 20.0 cm were created in the TPS. In the limit of isotropic irradiation, the mean dose at each shell was identical with the dose to an infinitely thin shell of an effective radius r dividing the original shell into two parts of equal volume. The mean dose to the shells was read off in TPS and plotted against the effective radius. In principle, a single beam would be sufficient for the calculation, as mean doses are additive. But a single beam is subject to direction dependent inaccuracies of voxel and slice based planning system and of accidental anisotropies. Therefore, a quasi-isotropic arrangement of sixteen beams was chosen  which was equivalent to multi-arc techniques for doses between 100 and 12% of the maximum dose, as illustrated in Additional file 1.
Conformity index and gradient index
A GI in stereotactic applications was aimed to be below 3.0 .
Additionally, the volume in which the dose exceeds 66.7% of the prescription dose, V 66.7% , was evaluated, known as “V12” for 18 Gy prescription in literature. However, within the study the dose to the isocentre was set to the maximum dose of 10 Gy. This choice does not restrict the generality of any results, as the scaling remains free. The prescription was set to the 70%-, 80%- and 90%-isodoses (these situations are called “D70%”, “D80%”, “D90%”); this means 7 Gy, 8 Gy or 9 Gy, respectively, were aimed to surround the PTV exactly in a way described below.
The MLC leaves were positioned using the “Expose-PTV” block margin function of the Pinnacle3 planning system in such a way that the MLC leaves touched the margin around the PTV in beam eye view projection. Also beams with PTV conformal, nearly circular blocks were created using the margin. The same margin was used for all beams of a given technique. To study the influence of prescription, the 70%-, 80%- and 90%-doses of the reference isocentre dose (=100%) were chosen as “PTV-surrounding”, respectively. They cover at least 99% of the PTV. A block thickness was chosen to produce the same transmission as the standard Elekta AgilityTM MLC with 0.5 cm leaf width at SID 100 cm. To carve out the impact of SVID and consequential effects of the penumbra changes, same conditions for block and MLC were simulated; the virtual block was placed in the MLC distance. Thus, the block behaved like a MLC with infinitely narrow leaves. To compare the techniques with each other, the same dose was prescribed to the isocentre; the PTV margin was iteratively adapted to achieve the same mean dose inside the PTV. Details of this method are described in Additional file 2. Changes of the penumbra were simulated exemplarily by a superposition of beams with different diameters. Beam charact eristics (profiles) were determined according to Additional file 3.
Paddick’s conformity index PCI for investigated constellations
MLC 0.5 cm (isocentric)
SID or SVID [cm]
Reduced SVID influenced both, penumbra and effective leaf width. The following sections were conceived to separate penumbra and lead width effects.
SID 100 vs. SVID 70/50
Gradient index GI for investigated constellations
MLC 0.5 cm (isocentric)
SID or SVID [cm]
Circular collimator vs. MLC
MLC at SVID 70/50 or optimal shape at SID 100?
Volume of 66.7% (V66.7%) of prescription dose for investigated constellations
MLC 0.5 cm (isocentric)
SID or SVID [cm]
Effects of superposition and penumbra increase
To evaluate the increase in the healthy tissue dose resulting from an enlarged penumbra for combined beam arrangements, we artificially raised the penumbra at constant SID using a superposition of beams with differing diameters.
MLC beam shaping
Validity of the planning study results
Note that the conclusions above probably are quite general and independent from the beam shaping device, although a special (spherical) PTV shape was chosen. The present study was performed for small spherical targets of different diameters. These targets stand for objects with various curvatures. The simple circular shape allows the definition of an optimal circular aperture, which is regarded as the limit of an infinitely small leaf width. All results were qualitatively independent from the PTV diameter. They were also independent from different prescription schemes, be that D70%, D80% or D90%.
The role of penumbra steepness
For circular collimator (Fig. 1) combined with reduced SVID, the improved healthy tissue sparing comes from the penumbra decrease. For MLC, the improvement in healthy tissue sparing at reduced SVID (Fig. 2) is dominated by the penumbra decrease, which can be inferred by comparing Fig. 2 vs. Fig. 1 and can be concluded from Fig. 4. As long as penumbra is decreased by 0.02 cm or more at reduced SVID, the MLC performs better than an ideal collimator at standard SID 100 cm. Although this was shown for the AgilityTM head, this result can be assumed relevant also for other MLCs, as the effect can be traced back to the geometrical penumbra. Independent from the present planning study, the importance of the penumbra can be deduced from more theoretical considerations (Bratengeier K, Holubyev K, Wegener S: Distance-dependent penumbra: Theoretical considerations and practical implications for stereotactic irradiation using a MLC, submitted).
In this study, the healthy tissue sparing effect of reduced SVID decreases for a larger PTV radius independently of beam shaping device, see Figs. 1 and 2. The sparing effect is dominated by penumbra decrease, which becomes less important for larger PTV: the volume of a thin layer around PTV, where penumbra dose dominates, becomes smaller relative to the PTV volume itself.
Advantages of reduced SVID
The effect of using MLC instead of ideal circular collimator (Fig. 3) is found (almost independent of SVID and prescription) at the level of 10% dose increase to the healthy tissue. The effect of reduced SVID is proven for SVID 70 cm, practical for head irradiations, at the level of 10% dose decrease due to decreased penumbra. Thus, at SVID 70 cm combined with MLC the two effects compensate and the plan quality is at least as good as at SID 100 cm combined with circular collimator (Fig. 4). In fact, the additional improved beam shaping due to narrower effective leaf widths ensures even further healthy tissue sparing.
Relation to neurosurgical literature data
The increase of quality by using SVID 70 cm or less is clearly significant and relevant: Dose to the surrounding decreases, as can be seen from GI and V 66.7% .
The GI for higher dose maxima and for more extended targets decreases below the intended GI <3.0 as demanded by the radiosurgery consortium , even for the 0.5 cm MLC at SVID 70 and below. For targets of 1.0 cm diameter, D50% should be used instead of D70%, because Paddick and Lippitz demonstrated a strong decrease of GI with increasing maximum dose  for typical beam profiles.
The presented results even assume infinitely variable collimator diameters, which will not be available for fixed sets of applicators of different diameters. In contrast, MLC and jaw can be steered in sub-millimeter range, as in the presented study. This fact additionally favours the MLC-SVID-approach. This is all the more the case for the shaping of non-spherical targets. Certainly, shaping by a MLC will be even more advantageous compared to circular applicators, if non-spherical targets are to be treated: the application time may be reduced. The treatment time is further decreased as a result of the inverse-quadratic law.
Recently, several authors pushed dynamic techniques using table movement  or complex leaf steering (see i.e., ) that require fail-safe and precise table and leaf movements, much more than needed for the present study. Therefore we excluded safety and precision aspects for the present study.
Using reduced SVID (e.g., in form of virtual isocentre) in combination with beam shaping device of any kind reduces the penumbra. Decreased penumbra provides an important contribution to the sparing of surrounding healthy tissue. The penumbra decrease obviously accounts for better healthy tissue sparing at reduced SVID. The present work proves that this effect dominates the decrease of healthy tissue dose at reduced SVID combined with MLC. In summary, for an Elekta Agility™ head, even a 0.5 cm leaf MLC at SVID 70 cm distance allows at least as good or even better healthy tissue sparing as an optimally shaped collimator at SID 100 cm.
In summary, using the SVID in reduced distance mode, the MLC-techniques could deliver approximately equal or better plan quality due to overcompensation of MLC “roughness” by the reduced penumbra.
The authors are convinced that the penumbra requires more attention in comparing studies, especially studies using different planning systems. This view is supported by theoretical work presently considered for publishing (Bratengeier K, Holubyev K, Wegener S: Distance-dependent penumbra: Theoretical considerations and practical implications for stereotactic irradiation using a MLC, submitted). Guidelines for stereotactic irradiation should not only define the leaf width but should also contain requirements for the penumbra .
Further studies should address more complex patient related targets and other types of linacs or sources combined with a virtual isocentre and its variable source-to-patient distances.
Many thanks to Johannes Greber for proofreading and to Otto Sauer for helpful discussions.
This publication was supported by the Open Access Publication Fund of the University of Wuerzburg.
Availability of data and materials
KB designed the study and performed most of the calculations and was responsible for the theoretical considerations. SW contributed the film dosimetry of real beams. BH performed parts of the planning study. KH discussed the study. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
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- Bortfeld T, Oelfke U, Nill S. What is the optimum leaf width of a multileaf collimator? Med Phys. 2000;27:2494–502.View ArticlePubMedGoogle Scholar
- Ohtakara K, Hayashi S, Tanaka H, Hoshi H. Dosimetric comparison of 2.5 mm vs. 3.0 mm leaf width micro-multileaf collimator-based treatment systems for intracranial stereotactic radiosurgery using dynamic conformal arcs: implications for treatment planning. Jpn J Radiol. 2011;29:630–8.View ArticlePubMedGoogle Scholar
- Monk JE, Perks JR, Doughty D, Plowman PN. Comparison of a micro-multileaf collimator with a 5-mm-leaf-width collimator for intracranial stereotactic radiotherapy. Int J Radiat Oncol Biol Phys. 2003;57:1443–9.View ArticlePubMedGoogle Scholar
- Tanyi JA, Kato CM, Chen Y, Chen Z, Fuss M. Impact of the high-definition multileaf collimator on linear accelerator-based intracranial stereotactic radiosurgery. Br J Radiol. 2011;84:629–38.View ArticlePubMedPubMed CentralGoogle Scholar
- Dvorak P, Georg D, Bogner J, Kroupa B, Dieckmann K, Potter R. Impact of IMRT and leaf width on stereotactic body radiotherapy of liver and lung lesions. Int J Radiat Oncol Biol Phys. 2005;61:1572–81.View ArticlePubMedGoogle Scholar
- Jin JY, Yin FF, Ryu S, Ajlouni M, Kim JH. Dosimetric study using different leaf-width MLCs for treatment planning of dynamic conformal arcs and intensity-modulated radiosurgery. Med Phys. 2005;32:405–11.View ArticlePubMedGoogle Scholar
- Dhabaan A, Elder E, Schreibmann E, Crocker I, Curran WJ, Oyesiku NM, Shu HK, Fox T. Dosimetric performance of the new high-definition multileaf collimator for intracranial stereotactic radiosurgery. J Appl Clin Med Phys. 2010;11:3040.View ArticlePubMedGoogle Scholar
- O’Malley L, Pignol JP, Beachey DJ, Keller BM, Presutti J, Sharpe M. Improvement of radiological penumbra using intermediate energy photons (IEP) for stereotactic radiosurgery. Phys Med Biol. 2006;51:2537–48.View ArticlePubMedGoogle Scholar
- Thomas SJ. Factors affecting penumbral shape and 3D dose distributions in stereotactic radiotherapy. Phys Med Biol. 1994;39:761–71.View ArticlePubMedGoogle Scholar
- Bratengeier K, Seubert B, Holubyev K, Schachner H. Considerations on IMRT for quasi-isotropic non-coplanar irradiation. Phys Med Biol. 2012;57:7303–15.View ArticlePubMedGoogle Scholar
- Paddick I. A simple scoring ratio to index the conformity of radiosurgical treatment plans. Technical note. J Neurosurg. 2000;93 Suppl 3:219–22.PubMedGoogle Scholar
- Paddick I, Lippitz B. A simple dose gradient measurement tool to complement the conformity index. J Neurosurg. 2006;105 Suppl:194–201.PubMedGoogle Scholar
- ICRU, “Prescribing, Recording, and Reporting Photon-Beam Intensity-Modulated Radiation Therapy (IMRT): Contents,” J ICRU 10, NP (2010).Google Scholar
- Torrens M, Chung C, Chung HT, Hanssens P, Jaffray D, Kemeny A, Larson D, Levivier M, Lindquist C, Lippitz B, Novotny Jr J, Paddick I, Prasad D, Yu CP. Standardization of terminology in stereotactic radiosurgery: Report from the Standardization Committee of the International Leksell Gamma Knife Society: special topic. J Neurosurg. 2014;121 Suppl:2–15.PubMedGoogle Scholar
- Prabhakar R, Rath GK, Haresh KP, Manoharan N, Laviraj MA, Rajendran M, Julka PK. A study on the tumor volume computation between different 3D treatment planning systems in radiotherapy. J Cancer Res Ther. 2011;7:168–73.View ArticlePubMedGoogle Scholar
- Adams EJ, Cosgrove VP, Shepherd SF, Warrington AP, Bedford JL, Mubata CD, Bidmead AM, Brada M. Comparison of a multi-leaf collimator with conformal blocks for the delivery of stereotactically guided conformal radiotherapy. Radiother Oncol. 1999;51:205–9.View ArticlePubMedGoogle Scholar
- Wilson B, Otto K, Gete E. A simple and robust trajectory-based stereotactic radiosurgery treatment. Med Phys. 2017;44:240–8.View ArticlePubMedGoogle Scholar
- Thomas EM, Popple RA, Markert JM, Fiveash JB. In reply: volumetric arc therapy (RapidArc) vs Gamma Knife radiosurgery for multiple brain metastases. Neurosurgery. 2015;76:E353–4.View ArticlePubMedGoogle Scholar
- Kocher M, Wittig A, Piroth MD, Treuer H, Seegenschmiedt H, Ruge M, Grosu AL, Guckenberger M. Stereotactic radiosurgery for treatment of brain metastases. A report of the DEGRO Working Group on Stereotactic Radiotherapy. Strahlenther Onkol. 2014;190:521–32.View ArticlePubMedGoogle Scholar
- Fenner J, Gwilliam M, Mehrem R, Bird A, Walton L. Analytical description of dose profile behaviour in Gamma Knife radiosurgery. Phys Med Biol. 2008;53:2035–49.View ArticlePubMedGoogle Scholar
- Micke A, Lewis DF, Yu X. Multichannel film dosimetry with nonuniformity correction. Med Phys. 2011;38:2523–34.View ArticlePubMedGoogle Scholar