You are viewing the site in preview mode

Skip to main content

Advertisement

Table 3 Excess lifetime attributable risk (LAR) VMAT vs 3DCRT

From: Estimation of second cancer risk after radiotherapy for rectal cancer: comparison of 3D conformal radiotherapy and volumetric modulated arc therapy using different high dose fractionation schemes

Organa 25 × 1.8 Gy (VMAT > LAR) 5 × 5 Gy (VMAT > LAR)
Median (%) 95 % CI p-value Median (%) 95 % CI p-value
Anus 0.0145 0.0016–0.0406 0.016 0.0088 0.0013–0.0241 0.013
Bladder 0.0934 0.0486–0.1491 <0.001 0.0988 0.0568–0.1572 <0.001
Bones R = 1 0.0066 −0.0223–0.0171 0.458 0.0057 −0.0089–0.0114 0.312
Bones R = 0.5 0.0040 −0.0057–0.0080 0.287 0.0026 −0.0019–0.0046 0.220
Bones R = 0.1 0.0003 −0.0002–0.0006 0.202 0.0001 −0.0001–0.0003 0.182
Colon 0.0768 0.0097–0.2674 0.015 0.0417 0.0051–0.1474 0.012
Sigmoid 0.0054 −0.0077–0.0152 0.367 0.0040 −0.0036–0.0106 0.241
Skin 0.0050 0.0027–0.0073 <0.001 0.0028 0.0014–0.0040 <0.001
Small bowel 0.0064 0.0137–0.0259 <0.001 0.0094 0.0052–0.0147 <0.001
Soft tissue R = 1 0.0195 0.0137–0.0259 <0.001 0.0094 0.0021–0.0042 <0.001
Soft tissue R = 0.5 0.0072 0.0050–0.0097 <0.001 0.0031 0.0050–0.0097 <0.001
Soft tissue R = 0.1 0.0005 0.0003–0.0006 <0.001 0.0002 0.0001–0.0003 <0.001
Prostate 0.0002 −0.0026–0.0043 0.787 0.0001 −0.0024–0.0034 0.893
Uterus 0.0089 0.0055–0.0555 0.063 0.0077 0.0042–0.0546 0.063
  1. VMAT volumetric modulated arc therapy, 3DCRT 3 dimensional conformal radiotherapy, R regeneration rate for soft tissue and bones, with possible sarcoma induction, CI confidence interval
  2. afemale/male data mixed if not otherwise indicated