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Table 2 Excess lifetime attributable risk (LAR) after RT

From: Estimation of second cancer risk after radiotherapy for rectal cancer: comparison of 3D conformal radiotherapy and volumetric modulated arc therapy using different high dose fractionation schemes

Organa Mean LAR VMAT (%) Mean LAR 3DCRT (%)
25 × 1.8 Gy 5 × 5 Gy 25 × 1.8 Gy 5 × 5 Gy
Anus 0.3330 0.1973 0.3098 0.1835
Bladder 0.2151 0.2260 0.1067 0.1144
Bones R = 1 0.1734 0.0881 0.1756 0.0864
Bones R = 0.5 0.0591 0.0273 0.0573 0.0257
Bones R = 0.1 0.0031 0.0013 0.0029 0.0013
Colon 1.0225 0.5677 0.8554 0.4754
Sigmoid 0.4732 0.2882 0.4981 0.3020
Skin 0.0519 0.0288 0.0461 0.0256
Small bowel 0.1328 0.1088 0.1240 0.0977
Soft tissue R = 1 0.1007 0.0474 0.0768 0.0357
Soft tissue R = 0.5 0.0344 0.0153 0.0254 0.0115
Soft tissue R = 0.1 0.0024 0.0011 0.0019 0.0008
Prostate 0.0354 0.0242 0.0346 0.0236
Ovaries 0.2756 0.1944 0.2838 0.2053
Uterus 0.1997 0.1383 0.1826 0.1220
All organs male R = 1 2.5380 1.5764 2.2270 1.3443
All organs male R = 0.5 2.3574 1.4835 2.0573 1.2593
All organs male R = 0.1 2.2694 1.4433 1.9795 1.2242
All organs female R = 1 2.9778 1.8849 2.6589 1.6480
All organs female R = 0.5 2.7972 1.7920 2.4892 1.5630
All organs female R = 0.1 2.7093 1.7518 2.4113 1.5279
  1. VMAT volumetric modulated arc therapy, 3DCRT 3 dimensional conformal radiotherapy, R regeneration rate for soft tissue and bones, with possible sarcoma induction
  2. afemale/male data mixed if not otherwise indicated