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Table 1 Significantly enriched pathways of genes differentially expressed in subclones SP and RP compared to the parental CAL-33 cells

From: Transcriptomic analyses of the radiation response in head and neck squamous cell carcinoma subclones with different radiation sensitivity: time-course gene expression profiles and gene association networks

CAL-33 SP vs parental Common signalling pathways CAL-33 RP vs parental
Transmembrane transport of small molecules Signaling by VEGF Nonhomologous end-joining (NHEJ)
GPCR ligand binding Extracellular matrix organization Homologous DNA pairing and strand exchange
Signaling by Rho GTPases RNA polymerase III transcription initiation CD28 dependent PI3K/Akt signaling
  Interferon signaling NOTCH1 intracellular domain regulates transcription
  Signaling by interleukins  
  Senescence-associated secretory phenotype (SASP)  
  NOD1/2 signaling pathway  
  TNFR1-induced NFkB signaling pathway  
  Toll-like receptors cascades  
  Death receptor signaling  
  MAPK1/MAPK3 signaling  
  1. Pathways common (middle) and specific to the radiosensitive (left) or radioresistant (right) phenotype are shown. The corresponding genes and their direction of regulation (up/down) are listed in Additional file 4: Table S3 and Additional file 6: Table S5