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Table 2 Dosimetric sensitivity of OAR clinical maximum dose, D2cm 3

From: Short-course PET based simultaneous integrated boost for locally advanced cervical cancer

  Bladder [Gy] Rectum [Gy] Sigmoid [Gy]
Param/Plan VMAT IMPT VMAT IMPT VMAT IMPT
Standard 1.77 ± 0.00 1.75 ± 0.00 1.75 ± 0.00 1.75 ± 0.01 1.75 ± 0.01 1.74 ± 0.00
SIB 1.92 ± 0.04 1.80 ± 0.01 1.85 ± 0.02 1.82 ± 0.02 1.81 ± 0.02 1.78 ± 0.01
SIB 3 mm shift 2.11 ± 0.08 2.02 ± 0.06 2.04 ± 0.04 2.00 ± 0.05 1.93 ± 0.05 1.88 ± 0.05
SIB 5 mm shift 2.23 ± 0.10 2.20 ± 0.09 2.16 ± 0.06 2.15 ± 0.06 2.02 ± 0.08 1.97 ± 0.08
  1. Dosimetric sensitivity analysis estimating increase of D2cm 3 to OARs from shifts towards the high dose area potentially caused by tumour shrinkage
  2. Values are EQD2 per fraction (α/β = 3) and in mean ± standard deviation of the mean