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Table 3 Diagnostic performance of volume measurements for depicting local residual cervical tumor using MRI before treatment, at first and final BCT

From: Consecutive magnetic resonance imaging during brachytherapy for cervical carcinoma: predictive value of volume measurements with respect to persistent disease and prognosis

Evaluation AUC Interclass coefficient (average) Cut-off Sensitivity and specificity
  Observer 1 Observer 2    Observer 1 Observer 2
      Sensitivity Specificity Sensitivity Specificity
Absolute volume analysis (n:35)
 (a) MRI before treatment 0.60 (0.30–0.90) 0.53 (0.29–0.78) 0.98 (0.96–0.99) 28,6 cm3 75 % (22–99) 45 % (28–64) 75 % (22–99) 55 % (36–72)
 (b) MRI at the first BCT* 0.91 (0.81–1.00) 0.89 (0.78–1.00) 0.95 (0.91–0.98) 11,5 cm3 100 % (40–100) 71 % (52–84) 100 % (40–100) 84 % (69–96)
 (c) MRI at the final BCT* 0.98 (0.94–1.00) 1.00 (1.00–1.00) 0.94 (0.89–0.97) 9,4 cm3 100 % (40–100) 94 % (77–100) 100 % (40–100) 100 % (86–100)
Volume regression analysis (n:35)
 ΔVolume: First BCT MRI/MRI before treatment 0.98 (0.93–1.00) 0.89 (0.72–1.00) 0.94 (0.87–0.97) 69 % 100 % (40–100) 58 % (39–75) 100 % (40–100) 65 % (45–80)
 ΔVolume: Final BCT MRI/MRI before treatment* 1.00 (1.00–1.00) 1.00 (1.00–1.00) 0.97 (0.95–0.99) 77 % 100 % (40–100) 97 % (81–100) 100 % (40–100) 100 % (86–100)
  1. AUC are given with the corresponding 95 % confidence intervals. *p < 0.05, compared to (a)