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Fig. 5 | Radiation Oncology

Fig. 5

From: Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization

Fig. 5

Effects of AZD6244, NVP-BEZ235 and IR on cell cycle phase distributions. Cell cycle phase distribution of SNB19 and A549 tumor cells treated with AZD6244 and/or NVP-BEZ235 before IR with 8 Gy. The cells were fixed 30 min, 24 or 48 h after IR, permeabilized, treated with RNase, stained with PI and analyzed for DNA content by flow cytometry. Data are presented as means (±SD) of G1- (light grey), S- (white) and G2/M-phase (dark grey) cells of at least three independent experiments for each cell line. Statistical significant changes assessed as specified in the Methods section are indicated by # P < 0.05

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