Objective consensus from decision trees
© Putora et al.; licensee BioMed Central Ltd. 2014
Received: 31 July 2014
Accepted: 21 November 2014
Published: 5 December 2014
Consensus-based approaches provide an alternative to evidence-based decision making, especially in situations where high-level evidence is limited. Our aim was to demonstrate a novel source of information, objective consensus based on recommendations in decision tree format from multiple sources.
Based on nine sample recommendations in decision tree format a representative analysis was performed. The most common (mode) recommendations for each eventuality (each permutation of parameters) were determined. The same procedure was applied to real clinical recommendations for primary radiotherapy for prostate cancer. Data was collected from 16 radiation oncology centres, converted into decision tree format and analyzed in order to determine the objective consensus.
Based on information from multiple sources in decision tree format, treatment recommendations can be assessed for every parameter combination. An objective consensus can be determined by means of mode recommendations without compromise or confrontation among the parties. In the clinical example involving prostate cancer therapy, three parameters were used with two cut-off values each (Gleason score, PSA, T-stage) resulting in a total of 27 possible combinations per decision tree. Despite significant variations among the recommendations, a mode recommendation could be found for specific combinations of parameters.
Recommendations represented as decision trees can serve as a basis for objective consensus among multiple parties.
Many clinical decisions in medicine are based on formal and informal consensus agreements and recommendations , especially when the level of evidence is not sufficient . For example, due to the lack of clinical studies many drugs used in adult medicine are not licenced for children, but may be applied in clinical routine . Likewise a growing number of treatable orphan diseases, defined by their low incidence , and distinct molecular aberrations in carcinomas  may never be amenable to large phase III studies. The trend towards personalized medicine and limited resources is forcing us to find solutions which do not exclusively rely on classical levels of evidence as presented by Sackett et al. . Even where evidence is available, this does not always translate into evidence-based practice due to lack of competency and is difficult to measure . Consensus methodologies may assist us in acquiring information beyond these gaps.
Several consensus methods exist, including the Delphi process, the nominal group technique and the consensus development conference ,. All of these modalities rely on discussion, negotiation, moderation and human judgement and are therefore subjective. In certain areas of medicine consensus meetings have been established as a pragmatic approach to provide guidance where evidence is not available -. In addition to “evidence-based” and “eminence-based” medicine , swarm-based medicine may provide guidance by extracting knowledge from the behaviour of the medical community . “Crowd wisdom” can be applied in single numerical estimates as well as for combinatorial problems .
Learning from information of simple structure is easy. When all parties provide a numeric value a consensus can be based on simple mathematical operands like mean, median or the most common value (mode). As the structure becomes more complex consensus ceases to be intuitive. When decisions are based on patient and disease characteristics such as three different age groups (e.g. <19, 19–64, >64 years), gender (male, female) and four different histologic types (e.g. in lung cancer: adenocarcinoma, squamous cell carcinoma, small cell or “not otherwise specified”) a total of 24 eventualities arise (3 × 2 × 4). By adding further criteria the number of possible combinations rises exponentially.
Multiple decision criteria can be integrated in a guideline with the help of decision trees, such as the clinical practice guidelines of the National Comprehensive Cancer Network .
This study aims to demonstrate how standardised elements (diagnostic nodes) , can be implemented to analyse and compare multiple recommendations from various parties in order to provide an account of unbiased consensus.
Decision trees can serve in decision support and are tree-like representations of decisions and their consequences. By connecting several elements from a starting point a decision tree can be constructed by adding possible options as branches. Recommendations (or actions) are situated at the end of the branches (analogous to leaves at the end of each branch). Nodes representing predefined parameters (diagnostic nodes ) were used to construct clinical decision trees. For example, the parameter gender is represented by two nodes (or branches): “male” or “female” and age e.g. by “<65 years” or “>65 years”. For later cross-comparison unified categories are important; should, for example, age be classified by one party by years (<19 years, 19 – 64 years, >64 years) and another party by category (age = old, age = young), an automated evaluation and comparison would be not possible.
Analogous to this procedure, the recommendations can be evaluated by considering every possible parameter combination of every decision tree.
To provide a clinical example, we collected and anonymized treatment recommendations on prostate cancer from 16 radiation oncology centres. The prescribed doses for radiotherapy depending on the T-stage, Gleason Score and PSA were collected. Additionally, we collected the criteria for starting androgen deprivation therapy as well as its duration. Only recommendations outside of clinical trials were considered; details on radiotherapy treatment such as margins, patient setup were not considered for this example. Obtaining the decision trees from individuals in various centres consisted of a first query on the general treatment strategy for prostate cancer. These were then specified in brief discussions (mostly per email) and converted into decision trees by PMP and CP. The decision trees were provided to the participating individuals for correction and approval. As the parameters used were identical among centres, the recommendations were converted into a decision tree format using these same parameters.
The decision trees were then analysed to determine the most common recommendations for each possible combination of parameters, based on this, the most common (mode) recommendation could be determined.
Ethics and consent
The presented research did not involve human subjects, material or data.
In order to determine the level of consensus among multiple parties, the individual positions of each party need to be available. In order to provide an objective basis for analysis, a collection of these recommendations in compatible format is required. The ideal format is a complete decision tree representing every possible combination of relevant parameters. However, this is often not readily available. Alternatively a short free-text version can be provided, the essence of which can be transformed into a decision tree. This decision-tree can then be iteratively checked against clinical scenarios and every possible combination of parameters. The parameters need to be clearly defined and agreed upon by all participating parties.
Of note, the implementation of each parameter within a recommendation tree is not mandatory. For instance, the parameter “histology” is not included in tree A but is implemented in others (Figure 1). In clinical routine not every parameter is used by all parties. Due to the inherent structure of a decision tree, the order of the parameters is not relevant as long as the parameter combinations lead to the same recommendation.
The mode decision tree is a transparent method to determine the agreement of multiple recommendations of varying structure within the same clinical context based on objective and standardized interpretation.
Areas of controversy and consensus can be equally represented. The completeness of the mode decision tree can provide users with guidance where traditional consensus methodologies or statements remain inconclusive.
Depending on the context, the anonymity of parties within a consensus effort may be of great value. Analysis of anonymously provided input can exclude any bias towards more influential parties and avoids direct confrontation among parties.
With traditional consensus-finding methods the effort per party increases with the number of parties ,, while with the mode-decision tree approach the effort per party is constant irrespective of the total number of participants.
Difficulty in implementing this methodology may result from the effort required to produce a recommendation tree covering all eventualities. Parties are faced with the problem of externalising intrinsic knowledge and every-day know-how in the form of a decision tree . In clinical practice, selected permutations (eventualities) may be very rare and physicians may never have to decide on certain issues. For example, the choice of chemotherapy for lung cancer in a 55-year old pregnant woman with renal insufficiency may never be needed. When recommendations are collected in decision tree format, the users must either provide a recommendation for these situations (as all permutations should be covered) or actively decide that they cannot. Interdependent hierarchical parameters are not suitable for automated decision tree comparison with this method. For example, should a decision tree include the recommendation “operation” and then further recommendations based on how this treatment worked “follow-up” after “gross total resection” or “adjuvant radiotherapy” after “subtotal resection” inconsistencies would arise. The latter recommendations are exclusive to their higher level criteria and not applicable without this condition. Depending on the complexity a potential approach might be to define one decision tree up to the recommendation (e.g. “operation”) and another one with this recommendation as a starting point.
An interesting option is party reselection: creating a mode decision tree from a subgroup (e.g. analysing the input from all participants of a single country). For individual questions, weighting may be based on properties of the parties (e.g. the number of patients treated per party). For example should all users within a set provide their recommendation trees and the number of patients treated, an estimate of how the majority of patients are treated can be made.
Digital communication may not replace direct contact where required, but may help determine various issues before any face-to-face meeting. Dynamic interpretation of up-to-date input allows for an automatic update; the mode decision tree can be instantly re-evaluated from current data.
A limitation of this approach is that its advantages become apparent only at a certain complexity range. Should the issue under evaluation involve e.g. two parameters and few users, a simple table would provide adequate visualisation. In the other extreme, should the context require many complex parameters the number of permutations may exceed millions. The methodology remains applicable, but the result may be too complex for practical interpretation. Feasibility is dependent on the question being asked, should the question involve the search for specific parameter combinations with complete consensus or a specific recommendation – the number of parameters may be higher and still result in a usable product (when filtered for complete consensus for example). Independent of the number of parameters, the system could be used to find the most common recommendation for a specific parameter combination. Typically, to provide feasible output for all parameter combinations the number of parameters should be kept in single digits.
Due to the accepted cancer classification (i.e. TNM-staging system), oncological diseases are very suitable to automated classifications. As demonstrated in the clinical example, when criteria are accepted among parties, it is possible to determine the specific recommendation from each party based on the decision trees (e.g. for a cT2b Gleason 8 prostate cancer with a PSA value of 15.2 ng/ml). The most common recommendation for such a patient can be determined from the mode decision tree. Besides having criteria multiple parties agree upon (e.g. the TNM staging system) it is important to have explicit and complete local standards in place to make any automated comparison feasible in routine practice. The authors are currently involved in projects testing this method in several clinical scenarios with various partners. Once a system of criteria is set up for a specific clinical problem and tested, adding further individuals/centres is associated with relatively little effort, such an approach may form the basis for possible routine clinical implementation. The results of the decision tree analysis, for example the mode decision tree may readily serve as a clinical decision making tool.
If the decision criteria implemented are identical to the criteria used in published guidelines an automated comparison of an individual tree or the mode decision tree to these guidelines would be possible. If this is the aim, parameters should be prospectively defined as it is possible that further criteria might be used in individual trees not considered in published guidelines.
The mode consensus does not provide any reasoning or justifications and should be interpreted for what it is – an objective analysis of the information provided by participants.
Diagnostic nodes can be used as a basis for a consensus-finding process from different recommendations within the same clinical context. The mode decision tree methodology may provide a useful instrument to enhance existing methodologies in consensus finding and is not limited to specific areas of clinical medicine. We could demonstrate the applicability on an abstract as well as a specific clinical example. As the mode decision trees represent an objective consensus based on current input, it may provide a valuable source of guidance on a case-by-case basis and thus be implemented in daily routine.
We would like to thank Jan Cuzy for programming a tool, which was used in the automated analyses of the presented results.
- Fink A, Kosecoff J, Chassin M, Brook RH: Consensus methods: characteristics and guidelines for use. Am J Public Health. 1984, 74: 979-983. 10.2105/AJPH.74.9.979.PubMed CentralView ArticlePubMedGoogle Scholar
- Putora PM, Oldenburg J: Swarm-based medicine. J Med Internet Res. 2013, 15: e207-10.2196/jmir.2452.PubMed CentralView ArticlePubMedGoogle Scholar
- Committee On D, Mmm: Off-label use of drugs in children. Pediatrics. 2014, 133: 563-567. 10.1542/peds.2013-4060.View ArticleGoogle Scholar
- Fuse ET, Kamimura M, Takeda Y, Kawaishi M, Kimura S, Niino H, Saito K, Kobayashi N, Kudo K: Response of a thymic mucoepidermoid carcinoma to combination chemotherapy with cisplatin and irinotecan: a case report. Lung Cancer. 2008, 59: 403-406. 10.1016/j.lungcan.2007.07.003.View ArticlePubMedGoogle Scholar
- Hundsberger T, Rohrbach M, Kern L, Rosler KM: Swiss national guideline for reimbursement of enzyme replacement therapy in late-onset Pompe disease. J Neurol. 2013, 260: 2279-2285. 10.1007/s00415-013-6980-5.View ArticlePubMedGoogle Scholar
- Fruh M: The search for improved systemic therapy of non-small cell lung cancer–what are today’s options?. Lung Cancer. 2011, 72: 265-270. 10.1016/j.lungcan.2011.02.020.View ArticlePubMedGoogle Scholar
- Sackett DL, Rosenberg WM, Gray JA, Haynes RB, Richardson WS: Evidence based medicine: what it is and what it isn’t. BMJ. 1996, 312: 71-72. 10.1136/bmj.312.7023.71.PubMed CentralView ArticlePubMedGoogle Scholar
- Ilic D: Assessing competency in evidence based practice: strengths and limitations of current tools in practice. BMC Med Educ. 2009, 9: 53-10.1186/1472-6920-9-53.PubMed CentralView ArticlePubMedGoogle Scholar
- Jones J, Hunter D: Consensus methods for medical and health services research. BMJ. 1995, 311: 376-380. 10.1136/bmj.311.7001.376.PubMed CentralView ArticlePubMedGoogle Scholar
- Lutz MP, Zalcberg JR, Ducreux M, Ajani JA, Allum W, Aust D, Bang YJ, Cascinu S, Holscher A, Jankowski J, Jansen EP, Kisslich R, Lordick F, Mariette C, Moehler M, Oyama T, Roth A, Rueschoff J, Ruhstaller T, Seruca R, Stahl M, Sterzing F, van Cutsem E, van der Gaast A, van Lanschot J, Ychou M, Otto F, First St Gallen EORTC Gastrointestinal Cancer Conference 2012 Expert Panel: Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer - differential treatment strategies for subtypes of early gastroesophageal cancer. Eur J Cancer. 2012, 48: 2941-2953. 10.1016/j.ejca.2012.07.029.View ArticlePubMedGoogle Scholar
- Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ, Panel m: Strategies for subtypes–dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 2011, 22: 1736-1747. 10.1093/annonc/mdr304.PubMed CentralView ArticlePubMedGoogle Scholar
- Shah C, Vicini F, Wazer DE, Arthur D, Patel RR: The American Brachytherapy Society consensus statement for accelerated partial breast irradiation. Brachytherapy. 2013, 12: 267-277. 10.1016/j.brachy.2013.02.001.View ArticlePubMedGoogle Scholar
- Rodrigues G, Macbeth F, Burmeister B, Kelly KL, Bezjak A, Langer C, Hahn C, Movsas B: Consensus statement on palliative lung radiotherapy: third international consensus workshop on palliative radiotherapy and symptom control. Clin Lung Cancer. 2012, 13: 1-5. 10.1016/j.cllc.2011.04.004.View ArticlePubMedGoogle Scholar
- Tjoumakaris FP, Pepe MD, Bernstein J: Eminence-based medicine versus evidence-based medicine: it’s okay for 12-year-old pitchers to throw curveballs; it’s the pitch count that matters. Phys Sportsmed. 2012, 40: 83-86. 10.3810/psm.2012.09.1984.View ArticlePubMedGoogle Scholar
- Yi SK, Steyvers M, Lee MD, Dry MJ: The wisdom of the crowd in combinatorial problems. Cognit Sci. 2012, 36: 452-470. 10.1111/j.1551-6709.2011.01223.x.View ArticleGoogle Scholar
- Mohler JL, Kantoff PW, Armstrong AJ, Bahnson RR, Cohen M, D’Amico AV, Eastham JA, Enke CA, Farrington TA, Higano CS, Horwitz EM, Kawachi MH, Kuettel M, Lee RJ, Macvicar GR, Malcolm AW, Miller D, Plimack ER, Pow-Sang JM, Richey S, Roach M, Rohren E, Rosenfeld S, Small EJ, Srinivas S, Stein C, Strope SA, Tward J, Walsh PC, Shead DA, Ho M, National comprehensive cancer network: Prostate cancer, version 1.2014. J Natl Compr Canc Netw. 2013, 11: 1471-1479.PubMedGoogle Scholar
- Putora PM, Blattner M, Papachristofilou A, Mariotti F, Paoli B, Plasswilm L: Dodes (diagnostic nodes) for guideline manipulation. J Radiat Oncol Inform. 2010, 2: 1-8.Google Scholar
- Niederman R, Leitch J: “Know what” and “know how”: knowledge creation in clinical practice. J Dent Res. 2006, 85: 296-297. 10.1177/154405910608500403.View ArticlePubMedGoogle Scholar
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