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Table 3 Clinical results of external beam radiation, brachytherapy boost, with or without chemotherapy

From: The safety and usefulness of neutron brachytherapy and external beam radiation in the treatment of patients with gastroesophageal junction adenocarcinoma with or without chemotherapy

Authors (Ref.) Hishikawa et al.[17] Flores et al.[23] Hareyama et al.[18] Sharma et al.[25] RTOG9207[16] Present study*
No. of pts. 148 171 161 100 50 197
BT Gy/fraction 12/1 15/1 15-20/NS 15-20/1 15/3 12-25/2-6
EBRTGy/fraction 60/30 40/15 47-70/25-35 50/28 50 30-60
CT (pts) No No No Yes Yes 88/197
Fistula (%) 5.3 5 1.2 12 12 8 (4.1%)
Bleeding (%) 0% 11 0 4 NS 13 (6.6%)
Ulcer (%) NS NS 3 29 NS NS
Stricture (%) 10 35 3 16 4 4 (2%)
Death rate (%) 3 0.6 0 4 8 0
OS (%) 37 (2 y) LD 33 (1 y) 43.3/Stage I, 8 (20 Gy) 49 (1 y) 57.1 (1 y)
8 (2 y) ED 26 (2 y) 21.1/Stage II, 23 (15 Gy)   35.1 (2 y)
  19 (3 y) (5 y) (5 y)   9.2 (5 y)
LRC (%) 64 (2 y) LD NS 31.7%(5 y) NS 35.9 (5 y)
  1. Abbreviations: CT Chemotherapy, HDR high dose rate, NS not stated, LD limited disease, ED extensive disease, y year.