Sequential change of T2-weighted MRI (upper column), Gd-enhanced T1-weighted MRI (middle column) and F-BPA-PET (lower column) of Case 1, a 44-year-old male. The timing of the MRIs is depicted above the MRIs. F-BPA-PET images were taken just before the BNCT and at 1 month and 10 months after the BNCT. These PET images show the gradual decrease of the tracer uptake as a promising effect of the BNCT. BV was started 10 months after the BNCT, and the MRI showed marked improvement of both perifocal edema and contrast enhancements by BV treatment.