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Table 3 Model selection for overall survival

From: The role of whole brain radiation therapy in the management of melanoma brain metastases

  Univariate analysis Multivariate analysis
  HR 95% CI p value HR 95% CI p value
Age at SRS (in years, continuous)* 1.00 0.98 – 1.01 0.46 0.99 0.98 – 1.01 0.37
Age at SRS >60 years 0.94 0.67 – 1.32 0.71    
Time from primary to brain met <39 mo. 1.11 0.79 – 1.55 0.56    
Extensive ECM (vs. Limited) 1.86 1.31 – 2.64 0.0006 1.78 1.25 – 2.53 0.001
Progressive ECD (vs. absent/stable) 1.22 0.82 – 1.82 0.32    
Number of brain metastases >1 1.40 0.99 – 1.98 0.06    
Diameter of brain metastasis >1 cm 1.24 0.89 – 1.75 0.21    
KPS 50 – 80 (vs. 90 or 100) 1.58 1.12 – 2.21 0.01 1.52 1.08 – 2.15 0.02
Omission of up-front WBRT 0.96 0.66 – 1.41 0.85    
  1. Abbreviations: HR hazard ratio, CI confidence interval, SRS stereotactic radiosurgery, Met metastasis, ECM extracranial metastases, ECD extracranial disease, KPS Karnofsky Performance Status, WBRT whole brain radiation therapy.
  2. *Age (as a continuous variable) was included in multivariate models for overall survival regardless of significance on univariate analysis.
  3. See Materials and Methods section and Table 1 for definitions of extensive and limited extracranial metastases.