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Table 2 Model selection for time to distant intracranial progression

From: The role of whole brain radiation therapy in the management of melanoma brain metastases

  Univariate analysis Multivariate analysis
  HR 95% CI p value HR 95% CI p value
Age at SRS >60 years 0.66 0.43 – 1.01 0.05 0.64 0.41 – 0.99 0.05
Time from primary to brain met <39 mo. 1.16 0.76 – 1.77 0.50    
Extensive ECM (vs. Limited)* 1.20 0.77 – 1.89 0.43    
Progressive ECD (vs. absent/stable) 1.15 0.70 – 1.87 0.58    
Number of brain metastases >1 1.45 0.93 – 2.24 0.10 1.90 1.18 – 3.06 0.008
Diameter of brain metastasis >1 cm 0.85 0.55 – 1.30 0.44    
KPS 50 – 80 (vs. 90 or 100) 0.90 0.58 – 1.41 0.65    
Omission of up-front WBRT 1.54 0.91 – 2.60 0.09 2.24 1.27 – 3.94 0.005
  1. Abbreviations: HR hazard ratio, CI confidence interval, SRS stereotactic radiosurgery, Met metastasis, ECM extracranial metastases, ECD extracranial disease, KPS Karnofsky Performance Status, WBRT whole brain radiation therapy.
  2. *See Materials and Methods section and Table 1 for definitions of “extensive” and “limited” extracranial metastases.