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Table 5 Multivariate analysis of lung and heart dosimetry and possible confounders in patients with chest wall and chest wall plus lymph nodes radiotherapy (n = 818)

From: No difference in dose distribution in organs at risk in postmastectomy radiotherapy with or without breast implant reconstruction

   Chest wall Chest wall plus lymph nodes
   n = 242 n = 576
Outcome variable Covariate OR (95%CI) P-value OR (95%CI) P-value
Lung V20Gy      
  IBR- vs. IBR+ 1.7 (0.5 to 5.8) 0.41 0.6 (0.4 to 1.0) 0.07
  Right vs. Left 1.1 (0.3 to 3.4) 0.91 1.1 (0.8 to 1.5) 0.59
  CWi ≤ median vs. CWi > median 0.7 (0.2 to 2.2) 0.50 1.7 (1.2 to 2.3) 0.004
Heart Dmean*   n = 118* n = 309*
  IBR- vs. IBR+ -# - 1.2 (0.5 to 3.1) 0.72
  Right vs. Left - - - -
  CWi ≤ median vs. CWi > median 0.2 (0.3 to 1.8) 0.16 0.9 (0.5 to 1.8) 0.82
  1. IBR, immediate breast reconstruction; CWi, chest wall index; OR, odds ratio; CI, confidence interval.
  2. Lung V20Gy, volume of ipsilateral lung tissue irradiated with 20 Gy (strata: ≤30% vs. >30%); Heart Dmean, mean dose delivered to heart (strata: ≤5 Gy vs. >5 Gy).
  3. *Analyzed for patients with left-sided radiation plans.
  4. #No patients with implant breast reconstruction received >5 Gy to heart.