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Table 4 Univariate analysis of lung and heart dosimetry and possible confounders in patients with chest wall only and chest wall plus lymph nodes irradiation (n = 818)

From: No difference in dose distribution in organs at risk in postmastectomy radiotherapy with or without breast implant reconstruction

   Chest wall, n = 242 Chest wall plus lymph nodes, n = 576
   Lung V20Gy Heart D mean* Lung V20Gy Heart D mean*
Confounders   ≤30% >30% OR (95%CI) P-value ≤5Gy >5Gy OR (95%CI) P-value ≤30% >30% OR (95%CI) P-value ≤5Gy >5Gy OR (95%CI) P-value
Reconstruction IBR- 155 7    75 8    293 201    236 36   
  IBR+ 75 5 1.5 (0.5 to 4.8) 0.52 35 0 -# -# 56 26 0.7 (0.4 to 1.1) 0.13 31 6 1.3 (0.5 to 3.3)  
Side Right 118 6    - -    165 102    - -   
  Left 112 6 1.1 (0.3 to 3.4) 0.93 110 8 - - 184 125 1.1 (0.8 to 1.5) 0.58 267 42 - -
Chest wall index CWi ≤ med 118 7    57 7    222 119    162 26   
  CWi > med 112 5 0.8 (0.2 to 2.4) 0.64 53 1 0.2 (0 to 1.3) 0.09 127 108 1.6 (1.1 to 2.2) 0.008 105 16 0.9 (0.5 to 1.9) 0.88
  1. CTV indicates clinical target volume; IBR, immediate breast reconstruction; CWi, chest wall index; med, median.
  2. Lung V20Gy, volume of lung tissue irradiated with 20 Gy (strata: ≤30% vs. >30%); Heart D mean, mean dose delivered to heart (strata: ≤5 Gy vs. >5 Gy);
  3. CTV V95%, percent of clinical target volume irradiated with ≤95% of isodose (strata: ≤median vs. >median).
  4. *Analyzed for patient with left-sided radiation plans (n = 118/242 and n = 309/576).
  5. #No patients with implant breast reconstruction received >5 Gy to heart.