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Table 1 Patient and tumor characteristics by age group (very elderly and younger status)

From: Stereotactic body radiotherapy for very elderly patients (age, greater than or equal to 85 years) with stage I non-small cell lung cancer

  All Very elderly ≥ 85 years Younger < 85 years p value
  (n = 81) (n = 20) (n = 61)  
Age (years)     
Median (range) 80 (64–93) 86 (85–93) 78 (64–84)  
Gender     0.002*
Female 17 9 8  
Male 64 11 53  
Performance status (ECOG)     0.44
0/1/2/3/4 55/24/2/0/0 14/6/0/0/0 41/18/2/0/0  
T stage     0.57
T1a/T1b/T2a 42/21/18 9/7/4 33/14/14  
Histology     0.62
Adenocarcinoma 35 11 24  
Squamous cell carcinoma 27 5 22  
Unclassified NSCLC 2 0 2  
Unproven 17 4 13  
Tumor location     0.64
Central/Peripheral 6/75 1/19 5/56  
Tumor opacity     0.41
Solid/GGO 79/2 20/0 59/2  
Operability     0.49
Operable/Inoperable 21/60 4/16 17/44  
Breath-hold     0.02*
Yes/No 50/31 8/12 42/19  
Total dose     0.49
48 Gy/60 Gy 60/21 16/4 44/17  
CTV (cc)     0.92
Mean ± SD (range) 19.5 ± 18.5 (1.1–91) 19.1 ± 19.3 (2.5–68) 19.7 ± 18.4 (1.1–91)  
PTV (cc)     0.46
Mean ± SD (range) 69.1 ± 49.7 (9.3–224) 76.3 ± 65.4 (14.3–224) 66.8 ± 43.8 (9.3–205)  
V20 (%)     0.64
Mean ± SD (range) 5.9 ± 3.2 (1.5–16) 6.2 ± 3.3 (1.6–14.9) 5.8 ± 3.2 (1.5–16)  
MLD (Gy)     0.30
Mean ± SD (range) 3.9 ± 1.6 (1.2–9.2) 4.2 ± 1.5 (1.6–7.6) 3.8 ± 1.6 (1.2–9.2)  
  1. Abbreviations: ECOG Eastern Cooperative Oncology Group, NSCLC non-small cell lung cancer, GGO ground-glass opacity, CTV clinical target volumes, PTV planning target volumes, V20 volumes of normal lung tissue exposed to  20 Gy, MLD mean lung doses.