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Table 4 Carotid-sparing IMRT studies in early laryngeal cancer

From: Risk-adapted partial larynx and/or carotid artery sparing modulated radiation therapy of glottic cancer

  Patients (n=) Tumor stage Prescription total/single dose (Gy) Objective Results
Rosenthal[20] 11 T1-2 N0 65/2.25 Comparison of opposed lateral fields and IMRT Best carotid-sparing with IMRT
Chera[15] 5 T1N0 63/2.25 Comparison of opposed lateral field, 3D-RT and IMRT Best carotid-sparing with IMRT
Sert[16] 5 T1N0 62.25/2.25 Comparison of opposed lateral field, 3D-RT and IMRT Best carotid-sparing with IMRT (V35, V50, V63), identical conformity
Atalar[17] 5 T1N0 63/2.25 Comparison of conformal RT, IMRT and IMAT More hot spots in IMRT and IMAT, less dose to carotids with IMRT/IMAT
Osman[21] 0 (comparative planning in 10 cases) T1N0 66/2 Comparison of conventional plans and IMRT (coplanar and non-coplanar) Contralateral vocal cord sparing best with single vocal cord RT IMRT
Mourad[19] 0 (comparative planning in 1 case) T1N0 63/2.25 Comparison of 2D, 3D and IMRT plans in a patient with complete left carotid artery occlusion Minimal dose to right carotid artery and pharyngeal constrictor with IMRT
Riegel[18] 0 (comparative planning in 11 cases) T1-2 N0 63/2.25 Comparison of lateral opposed fields, VMAT (full-arc, half arc) and IMRT Full-arc VMAT offers best carotid sparing (and highest mean normal tissue dose), static IMRT produced next-best carotid sparing
  1. IMRT intensity-modulated radiotherapy, IMAT intensity-modulated arc therapy, VMAT volumetric-modulated arc therapy.