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Table 4 Analysis of dose-volume parameter effect on late toxicity

From: Different rectal toxicity tolerance with and without simultaneous conventionally-fractionated pelvic lymph node treatment in patients receiving hypofractionated prostate radiotherapy

  All (212) ENI (103) No ENI (109)
  HR [95% CI] p HR [95% CI] p HR [95% CI] p
    GU    
Bladder volume 0.996 [0.991 – 1.001] 0.154 0.996 [0.989 – 1.004] 0.353 0.996 [0.988 – 1.003] 0.242
Bladder mean dose 1.000 [1.000 – 1.001] 0.186 1.001 [1.000 – 1.001] 0.059 1.000 [0.999 – 1.001] 0.945
V 40 (percent) 1.016 [0.996 – 1.036] 0.119 1.032 [1.003 – 1.062] 0.029 0.964 [0.908 – 1.023] 0.228
V 60 (percent) 1.021 [0.988 – 1.056] 0.205 1.029 [0.990 – 1.069] 0.150 0.992 [0.828 – 1.188] 0.931
V 60 (percent) 1.034 [0.974 – 1.098] 0.270 1.044 [0.975 – 1.118] 0.213 1.166 [0.820 – 1.656] 0.955
V 40 (absolute) 1.007 [0.968 – 1.047] 0.849 1.001 [0.992 – 1.011] 0.806 1.001 [0.980 – 1.022] 0.616
V 60 (absolute) 1.007 [0.968 – 1.047] 0.733 1.002 [0.953 – 1.053] 0.939 1.017 [0.952 – 1.087] 0.616
V 70 (absolute) 1.016 [0.944 – 1.094] 0.616 1.007 [0.917 – 1.106] 0.877 1.031 [0.909 – 1.170] 0.631
ADT   0.193 -   1.647 [0.805 – 3.367] 0.172
ENI 1.517 [0.810 – 2.841] 0.193    -  
Volume of PTV LN -   1.002 [0.998 – 1.006] 0.245 -  
    GI    
Rectum volume 1.001 [0.999 – 1.011] 0.081 1.009 [1.002 – 1.016] 0.017 0.973 [0.934 – 1.014] 0.196
Rectum mean dose 1.000 [0.999 – 1.001] 0.401 0.999 [0.999 – 1.000] 0.187 1.000 [0.999 – 1.001] 0.769
V 40 (percent) 0.993 [0.967 – 1.021] 0.632 0.983 [0.952 – 1.015] 0.287 0.997 [0.938 – 1.059] 0.923
V 60 (percent) 0.950 [0.847 – 1.065] 0.376 0.968 [0.861 – 1.089] 0.588 0.905 [0.706 – 1.163] 0.439
V 70 (percent) 1.049 [0.827 – 1.332] 0.692 1.057 [0.814 – 1.374] 0.676 1.033 [0.621 – 1.718] 0.901
V 40 (absolute) 1.011 [0.996 – 1.026] 0.158 1.011 [0.995 – 1.028] 0.183 0.959 [0.882 – 1.042] 0.319
V 60 (absolute) 1.049 [0.962 – 1.143] 0.282 1.077 [0.989 – 1.173] 0.087 0.796 [0.598 – 1.060] 0.119
V 70 (absolute) 1.249 [1.008 – 1.548] 0.042 1.314 [1.047 – 1.648] 0.018 0.778 [0.390 – 1.551] 0.476
ADT 1.199 [0.719 – 2.000] 0.486    1.548 [0.633 – 3.788] 0.338
ENI 3.023 [1.089 – 8.392] 0.034 -   1.548 [0.633 – 3.788] 0.338
Volume of PTV LN -   0.999 [0.996 – 1.002] 0.426 -  
  1. Bolded text indicates a statistically significant difference.