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Table 5 Clinical and tumor characteristics assosiated with an increase in CP score

From: Significance of an increase in the Child-Pugh score after radiotherapy in patients with unresectable hepatocellular carcinoma

Variables No toxicity Toxicity p value
Gender    
  Male 45 35 0.475
  Female 11 12  
Age    
  Median 60 57 0.142
  Range 21-80 40-80  
ECOG PS    
  0 18 20 0.275
  1 38 27  
Hepatitis    
  B 40 33 0.892
  Others 16 14  
Liver cirrhosis    
  No 19 13 0.493
  Yes 37 34  
PVTT    
  No 30 15 0.027
  Yes 26 32  
AFP    
  ≤400 40 27 0.138
  >400 16 20  
Pretreatment CP class    
  A 52 39 0.120
  B 4 8  
PTV    
  ≤225 cm3 42 18 <0.001
  >225 cm3 14 29  
BED    
  ≤70 Gy 22 27 0.066
  >70 Gy 34 20  
Hypofractionation    
  <4 Gy per fraction 39 24 0.054
  ≥4 Gy per fraction 17 23  
  1. Abbreviations: HR hazard ratio, CI confidence interval, ECOG PS Eastern Cooperative Oncology Group performance status, PVTT portal vein tumor thrombosis, AFP alpha-fetoprotein, CP Child-Pugh, PTV planning target volume, BED biologically effective dose.