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Table 4 Predictive factors that influence the overall mortality

From: Significance of an increase in the Child-Pugh score after radiotherapy in patients with unresectable hepatocellular carcinoma

Variables Univariate analysis Multivariate analysis
  HR (95% CI) p value HR (95% CI) p value
Gender (female) 1.329 0.262   
(0.807-2.192)
Age 1.002 0.826   
(0.982-1.023)
ECOG PS (1) 1.052 0.816   
(0.686-1.613)
Hepatitis (B) 1.068 0.780   
(0.672-1.697)
Liver cirrhosis (presence) 1.371 0.175   
(0.868-2.164)
PVTT (presence) 1.457 0.079   
(0.957-2.217)
AFP (>400) 1.798 0.083   
(0.926-3.484)
Pretreatment CP class (B) 1.834 0.038 1.524 0.255
(1.033-3.257) (0.738-3.144)
PTV (>225 cm3) 2.057 0.001 1.821 0.010
(1.355-3.125) (1.157-2.865)
BED (>70 Gy) 0.839 0.448   
(0.532-1.322)
Hypofractionation (4 Gy per fraction) 0.731 0.146   
(0.479-1.116)
An increase in CP score after RT (≥2) 2.283 <0.001 1.795 0.015
  (1.494-3.484)   (1.121-2.881)  
  1. Abbreviations: HR hazard ratio, CI confidence interval, ECOG PS Eastern Cooperative Oncology Group performance status, PVTT portal vein tumor thrombosis, AFP alpha-fetoprotein, CP Child-Pugh, PTV planning target volume, BED biologically effective dose.