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Table 2 Details of recurrence patterns and salvage treatments

From: Initial and cumulative recurrence patterns of glioblastoma after temozolomide-based chemoradiotherapy and salvage treatment: a retrospective cohort study in a single institution

Patient no. Patterns of recurrence Salvage treatmentb Current status
Initial Cumulativea
Central In-field Marginal Out-field Distant Surgery SRT Chemo
1 Distant - - - - - 0 0 - Dead
2 Central 3 0 1 0 2 Central (1) Central(1) ICE, BEV Dead
Marginal (1)
3 Distant - - - - - 0 0 ICE Dead
4 Out-field 0 0 0 2 0 0 Out-field (2) ICE, BEV, Others Dead
5 Central 1 0 0 0 1 Central (2) Central (1) ICE Dead
6 Central 1 0 0 0 0 Central (2) 0 ICE Dead
7 Central 2 0 1 0 2 Central (2) Central (1) ICE, BEV, Others Dead
8 Central 2 0 0 0 1 0 0 ICE, BEV Dead
9 In-field 1 0 1 2 1 Central + In-field (1) Marginal (1) ICE, BEV Dead
10 Central 0 1 0 1 1 Central (1) 0 ICE, BEV Dead
11 Central 2 1 0 0 1 Central (1) Central (2) ICE, BEV, Others Dead
In-field (1)
12 Out-field 0 0 0 2 1 0 Out-field (1) ICE, BEV Alive
13 Central 0 0 0 0 1 0 0 ICE Dead
14 Central 2 0 0 0 1 Central (2) Central (1) ICE, BEV Dead
15 In-field - - - - - 0 In-field (1) - Alive
16 Central, In-field 1 1 0 0 1 Central (1) Central + ICE, BEV Dead
In-field (1)
17 Central, Distant - - - - - 0 0 - Dead
18 Central 1 1 0 0 1 Central (1) 0 ICE Dead
In-field (1)
19 Central 1 0 0 0 1 Central (2) 0 ICE Dead
20 In-field 0 1 0 1 1 0 In-field (1) ICE, Others Alive
In-field + Out-field + Distant (1)
21 Central, Distant - - - - - 0 0 - Dead
  1. BEV: bevacizumab.
  2. ICE: ifosfamide, carboplatin, and etoposide.
  3. SRT: stereotactic radiotherapy.
  4. aCumulative recurrence patterns were classified and counted each time a new recurrent lesion was detected in follow-up MRI scans after the initial recurrence. Five patients had no scans after the initial recurrence and were excluded from the analysis of cumulative recurrence.
  5. bRegarding local salvage, recurrence patterns of treated lesions are described; repeat local salvage numbers are also indicated.