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Table 7 Overview of published clinical data on hypofractionation in prostate cancer

From: Acute toxicity profile in prostate cancer with conventional and hypofractionated treatment

References Fractions Fraction size Total dose weeks NTD2 for α/β Acute toxicity
      α/β = 1.5 α/β =3 α/β =10 GI (%) GU (%)
Livsey et al. [12] 6 6 36 3 77.1 64.8 48   
Kupelian et al. [9] 28 2.5 70 5.5 80 77 72.9 19 15
Soete et al. [15] 16 3.5 56 4 80 72.8 63 38 39
Madsen et al. [10] 5 6.7 33.5 1 78.5 65 46.6 22 13
Pollack et al. [13] 26 2.7 70.2 5 84.2 80.5 74.3 18 48
Martin et al. [14] 20 3 60 4 77.1 72 65 12 25
FAMEMA trial (present study) 23 3 69 4.5 88.7 83 76 20.5% 23.2%
  1. Abbreviations: GI = gastrointestinal;GU = genitourinary; NTD2 = Equivalent dose (Gy) for 2-Gy fractionation; BED = biological effective dose.