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Table 5 Literature review of IORT for cervical cancer

From: Intraoperative Electron Beam Radiotherapy (IOERT) in the management of locally advanced or recurrent cervical cancer

Series Date Patients (n) Advanced primary or recurrent IORT modality Median IORT dose (Gy) Crude LRR Median survival (mos) OS
Hicks et al [18]. 1993 13 Recurrent Orthovoltage 15 7/13 7 -
Konski et al [24]. 1993 8 Primary IOERT 20 7/8 27 -
   5 Recurrent IOERT 20 - 9 -
Gerard et al [17]. 1994 20 Primary IOERT - 4/20 - 75% at 18 mos
   34 Recurrent IOERT - 6/34 - 32% at 4 yrs
Stelzer et al [23]. 1995 22 Recurrent IOERT 22 10/22 26 43% at 5 yrs (CSS)
Mahé et al [19]. 1996 70 Recurrent IOERT 19 50/67 11 8% at 3 yrs
del Carmen et al [14]. 2000 5 Recurrent IOERT 15 2/5 - -
Gemignani et al [16]. 2001 9 Recurrent HDR-BT 14 - - 54% at 3 yrs
Martinez-Monge et al [20]. 2001 31 Primary IOERT 12 6/31 - 58% at 10 yrs
   36 Recurrent IOERT 15 18/36 - 14% at 10 yrs
Roth et al [21]. 2003 1 Recurrent HDR-BT 15 0/1 20 -
Tran et al [22]. 2007 17 Recurrent Orthovoltage 11.5 - - 47% at 5 yrs (CSS)
Current series 2012 13 Primary IOERT 12.5 4/13 13 29% at 3 yrs
   73 Recurrent IOERT 17.5 33/73 17 25% at 3 yrs
  1. Abbreviations: IORT = intraoperative radiotherapy; LRR = locoregional recurrence; OS = overall survival; IOERT = intraoperative electron beam radiotherapy; CSS = cause-specific survival; HDR-BT = high-dose rate brachytherapy.