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Table 4 Multivariate analysis of potential prognostic risk factors in patients treated with IOERT for recurrent cervical cancer

From: Intraoperative Electron Beam Radiotherapy (IOERT) in the management of locally advanced or recurrent cervical cancer

Variable CC LRC CSS
HR 95% CI P HR 95% CI P HR 95% CI P
High grade tumor 0.92 0.17-3.97 0.91 0.78 0.24-2.14 0.64 0.40 0.14-0.96 0.04
Recurrence ≤6 months after initial therapy 0.24 0.03-4.88 0.28 0.32 0.08-2.15 0.21 0.10 0.03-0.40 0.002
Previous RT 2.21 0.57-9.00 0.25 1.26 0.43-3.51 0.66 1.40 0.60-3.20 0.43
Pelvic exenteration 4.18 1.15-20.62 0.02 3.01 1.19-8.55 0.02 1.75 0.83-3.90 0.15
Surgical margin grade          
 R0 vs. R2 0.69 0.13-3.52 0.65 1.60 0.56-4.61 0.38 2.25 0.94-5.42 0.07
 R1 vs. R2 0.54 0.12-1.90 0.35 1.20 0.47-2.89 0.69 2.02 0.92-4.34 0.08
 R0 vs. R1 1.29 0.34-5.61 0.72 1.33 0.51-3.64 0.56 1.11 0.50-2.50 0.79
Perioperative RT 5.54 1.52-23.86 0.009 3.38 1.30-9.19 0.01 2.09 0.93-4.67 0.07
Perioperative systemic therapy 0.98 0.33-3.10 0.97 0.74 0.33-1.63 0.45 0.86 0.44-1.69 0.66