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Table 3 Univariate analysis of potential prognostic risk factors in patients treated with IOERT for recurrent cervical cancer

From: Intraoperative Electron Beam Radiotherapy (IOERT) in the management of locally advanced or recurrent cervical cancer

Variable 3-year CC, % P 3-year LRC, % P 3-year FFDR, % P 3-year CSS, % P
Tumor grade   0.68   0.61   0.46   0.21
 Low 92   50   71   59  
 High 65   47   42   25  
Previous RT   0.22   0.61   0.08   0.28
 Yes 71   54   50   33  
 No 66   46   37   26  
Multiple previous recurrences   0.95   0.20   0.77   0.72
 Yes 65   45   50   32  
 No 71   54   47   31  
Time period of IOERT   0.16   0.13   0.63   0.45
 1983-1996 60   40   45   27  
 1997-2010 81   68   50   39  
Time from diagnosis to recurrence   0.76   0.47   0.13   0.001
 ≤6 months 80   60   25   0  
 >6 months 70   52   49   34  
Tumor size   0.67   0.97   0.46   0.82
 <3 cm 44   35   42   22  
 ≥3 cm 74   55   48   34  
Type of surgery   0.13   0.12   0.60   0.30
 Exenteration 77   58   46   41  
 Less extensive resection 66   49   48   27  
Surgical margin grade   0.17   0.13   0.004   0.04
 R0 82   71   61   45  
 R1 55   36   45   27  
 R2 81   53   25   14  
Pelvic sidewall involvement   0.77   0.76   0.89   0.37
 Yes 69   50   46   28  
 No 70   55   48   39  
Perioperative RT   0.13   0.11   0.34   0.29
 Yes 76   60   44   36  
 No 52   33   60   22  
Perioperative systemic therapy   0.35   0.97   0.44   0.81
 Yes 74   54   53   31  
 No 66   51   43   32  
  1. Abbreviations: CC = central control; LRR = locoregional control; FFDR = freedom from distant recurrence; CSS = cause-specific survival; RT = radiotherapy; IOERT = intraoperative electron beam radiotherapy.