You are viewing the site in preview mode

Skip to main content

Advertisement

Table 6 Univariate and multivariate analysis of prognostic factors for OS

From: Phase I study of hypofractionated intensity modulated radiation therapy with concurrent and adjuvant temozolomide in patients with glioblastoma multiforme

  Univariate Multivariate
Variable HR 95% CI P HR 95% CI P
KPS       
≥ 80 vs. 70 1.32 0.50-3.46 0.573    NS
RPA class       
Class III vs. Class IV and V 2.51 0.56-11.20 0.228    NS
Adjuvant TMZ       
≥3 cycles vs. < 3 cycles 0.79 0.64-0.97 0.024 0.83 0.69-0.99 0.042
Extent of resection       
GTR vs. biopsy or STR 1.99 0.45-8.86 0.368    NS
Time interval between the date of surgery and start of RT       
≥ 6 weeks vs. < 6 weeks 3.18 1.20-8.40 0.02 2.94 1.06-8.18 0.039
  1. Abbreviations: OS: overall survival; HR: hazard ration; CI: confidence interval; KPS: Karnofsky performance status; RPA: recursive partitioning analysis; TMZ: Temozolomide; GTR: gross total resection; STR: subtotal resection; RT: radiation therapy.