You are viewing the site in preview mode

Skip to main content

Advertisement

Table 5 Univariate and multivariate analysis of prognostic factors for PFS

From: Phase I study of hypofractionated intensity modulated radiation therapy with concurrent and adjuvant temozolomide in patients with glioblastoma multiforme

  Univariate Multivariate
Variable HR 95% CI P HR 95% CI P
KPS       
≥ 80 vs. 70 0.4 0.16-0.99 0.048 0.29 0.09-1.00 0.049
RPA class       
Class III vs. Class IV and V 0.34 0.10-1.11 0.075    NS
Adjuvant TMZ       
≥3 cycles vs. < 3 cycles 0.84 0.72-0.982 0.028 0.79 0.65-0.96 0.02
Extent of resection       
GTR vs. biopsy or STR 0.54 0.15-1.91 0.339    NS
Time interval between the date of surgery and start of RT       
≥ 6 weeks vs. < 6 weeks 1.08 0.45-2.59 0.867    NS
  1. Abbreviations: PFS: progression free survival; HR: hazard ration; CI: confidence interval; KPS: Karnofsky performance status; RPA: recursive partitioning analysis; TMZ: Temozolomide; GTR: gross total resection; STR: subtotal resection; RT: radiation therapy.