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Table 3 The patterns of failure following radiation for GBM with respect to radiation techniques, radiation dose, and percentage of in-field failure

From: Concurrent bevacizumab and temozolomide alter the patterns of failure in radiation treatment of glioblastoma multiforme

Study Year Number of patients Radiation techniques Dose % In-field failure
Current study 2013 23 IMRT 60 Gy 25% (p < .05)
Lee [22] 1999 36 3DCRT 70 or 80 Gy 89%
Hess [24] 1994 66 3DCRT 60 Gy 86%
Garden [7] 1991 39 3DCRT 65.4 Gy 71%
Wallner [8] 1989 25 Whole Brain + Boost 70 Gy 75%
Fitzek [6] 1999 23 Sequential Boost 3DCRT with photons and protons 90 CGE 78%
Chan [5] 2002 34 Sequential Boost 3DCRT 90 Gy 91%