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Table 2 Multivariate proportional hazards models (n = 103)

From: Vascular endothelial growth factor (VEGF) expression in locally advanced prostate cancer: secondary analysis of radiation therapy oncology group (RTOG) 8610

Endpoints Covariate Comparison HR* 95% CI p-value**
Overall Survival VEGF 0-1 vs. RL   
2-3 1.314 (0.850, 2.030) 0.219
Treatment arm STAD + RT arm vs. RL   
RT alone arm 1.268 (0.821, 1.959) 0.285
Age < 71 vs. RL   
≥ 71 1.708 (1.112, 2.625) 0.015
Combined Gleason Score 2-6 vs. RL   
7-10 1.416 (0.883, 2.270) 0.149
Clinical Stage T2 vs. RL   
T3 1.026 (0.626, 1.681) 0.918
Distant Metastasis VEGF 0-1 vs. RL   
2-3 1.090 (0.629, 1.889) 0.760
Treatment arm STAD + RT arm vs. RL   
RT alone arm 1.472 (0.861, 2.517) 0.160
Age < 71 vs. RL   
≥71 1.096 (0.631, 1.903) 0.740
Combined Gleason Score 2-6 vs. RL   
7-10 2.528 (1.358, 4.705) 0.003
Clinical Stage T2 vs. RL   
T3 0.819 (0.446, 1.504) 0.520
Local Progression VEGF 0-1vs. RL   
2-3 1.160 (0.662, 2.030) 0.600
Treatment arm STAD + RT arm vs. RL   
RT alone arm 1.306 (0.726, 2.349) 0.370
Age < 71 vs. RL   
≥71 0.873 (0.496, 1.536) 0.640
Combined Gleason Score 2-6 vs. RL   
7-10 0.757 (0.426, 1.344) 0.340
Clinical Stage T2 vs. RL   
T3 0.657 (0.361, 1.197) 0.170
Disease-free Survival VEGF 0-1vs. RL   
2-3 0.859 (0.573, 1.286) 0.461
Treatment arm STAD + RT arm vs. RL   
RT alone arm 2.102 (1.370, 3.227) < 0.001
Age < 71 vs. RL   
≥ 71 0.932 (0.618, 1.407) 0.738
Combined Gleason Score 2-6 vs. RL   
7-10 1.717 (1.048, 2.813) 0.032
Clinical Stage T2 vs. RL   
T3 0.887 (0.539, 1.458) 0.626
Biochemical Failure VEGF 0-1vs. RL   
2-3 1.041 (0.655, 1.652) 0.870
Treatment arm STAD + RT arm vs. RL   
RT alone arm 1.995 (1.250, 3.186) 0.004
Age < 71 vs. RL   
≥ 71 0.770 (0.483, 1.229) 0.270
Combined Gleason Score 2-6 vs. RL   
7-10 1.403 (0.785, 2.508) 0.250
Clinical Stage T2 vs. RL   
   T3 0.961 (0.503, 1.837) 0.900
  1. * A hazard ratio (HR) is defined as the ratio of the estimated hazard for those with a variable value 1 to the estimated hazard for those with a variable value 0. A hazard ratio of 1 indicates no difference between two subgroups.
  2. ** P-values from Chi-square test using Cox (overall survival and disease-free survival) or Fine & Gray (distant metastasis, local progression, and biochemical failure) Proportional Hazards Model.
  3. indicates the statistically significant at the significance level of 0.05.
  4. 1 patient without Gleason score is not included.