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Table 1 Median saliva flow rates, MUC5B and total protein levels 12 months after RT in patients with and without severe xerostomia during daytime and/or nighttime

From: MUC5B levels in submandibular gland saliva of patients treated with radiotherapy for head-and-neck cancer: A pilot study

   No/mild xerostomia Severe xerostomia  p 
(n = 12) (n = 17)
SMG flow rate ml/10 min 0.69 0.80 0.66
WS flow rate (PG + SMG) ml/10 min 3.35 2.80 0.82
MUC5B concentration U 0.14 0.01 0.22
Undetectable MUC5B * % 25 47 0.27
MUC5B x flow rate μg/10 min 15.0 1.3 0.37
Total protein mg/ml 0.87 0.82 0.76
  1. Abbreviations: SMG = submandibular gland, WS = whole saliva, PG = parotid gland, U = units; normalized to 1 for unstimulated saliva in healthy controls.
  2. * MUC5B level in SMG saliva equal to 0.00 U at 12 months after RT.
  3. The MUC5B x flow rate product (in μg/10 min) was calculated by multiplying the MUC5B concentration (in U) and SMG flow rate (in ml/10 min) for each patient at 12 months after RT and assuming 1 Unit is 230 μg/ml of MUC5B [13].