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Table 2 Incidence and maximum severity of toxicities (MedDRA classification)

From: Concurrent chemoradiation of metastases with capecitabine and oxaliplatin and 3D-CRT in patients with oligometastatic colorectal cancer: results of a phase I study

  Dose level 1 Dose level 2
CTC grade 1/2 3 4 1/2 3 1/2 3 4
MedDRA Code (n = 9 events) No. of Patients
Infections and infestations
Infection 0 2 0 0 0 0 2 0
Immune system disorders
Anaphylactic reaction 0 0 1 0 0 0 0 1
Nervous system disorders
Peripheral sensory neuropathy 2 0 0 1 0 3 0 0
Eye disorders
Conjunctival haemorrhage 1 0 0 0 0 1 0 0
Vision blurred 1 0 0 0 0 1 0 0
Disorder sight 1 0 0 0 0 1 0 0
Abnormal sensation in eye 1 0 0 0 0 1 0 0
Vascular disorders
Flushing 2 0 0 0 0 2 0 0
Hypotension 1 0 0 1 0 2 0 0
Thrombophlebitis 1 0 0 0 0 1 0 0
Respiratory, thoracic and mediastinal disorders
Dyspnoea 0 1 0 0 0 0 1 0
Gastrointestinal disorders
Abdominal pain 0 0 0 1 0 1 0 0
Abdominal distension 1 0 0 0 0 1 0 0
Vomiting 0 0 0 1 0 1 0 0
Obstipation 2 0 0 0 0 2 0 0
Mucous stools 1 0 0 0 0 1 0 0
Nausea 3 0 0 2 0 5 0 0
Abdominal discomfort 1 0 0 0 0 1 0 0
Epigastric discomfort 0 0 0 1 0 1 0 0
Skin and subcutaneous tissue disorders
Dermatitis 1 0 0 2 0 3 0 0
Musculoskeletal and connective tissue disorders
Bone pain 1 0 0 0 0 1 0 0
Myalgia 1 0 0 0 0 1 0 0
Pain in extremity 1 0 0 0 0 1 0 0
Renal and urinary disorders
Bladder discomfort 2 0 0 0 0 2 0 0
General disorders and administration site conditions
Injection site erythema 0 0 0 1 0 1 0 0
Pyrexia 1 0 0 1 0 2 0 0
Injection site paraesthesia 0 0 0 1 0 1 0 0
Mucosal inflammation 1 0 0 0 0 1 0 0
Pain 3 1 0 1 0 4 1 0
Chills 1 0 0 1 0 2 0 0
Investigations
Blood amylase increased 1 0 0 0 0 1 0 0
Blood bilirubin increased 2 0 0 3 0 5 0 0
Blood pressure increased 0 0 0 2 0 2 0 0
Blood urea increased 1 0 0 0 0 1 0 0
Blood urea decreased 0 0 0 2 0 2 0 0
C-reactive protein increased 4 0 0 1 0 5 0 0
Blood fibrinogen increased 1 0 0 0 0 1 0 0
Gamma-glutamyltransferase increased 4 0 0 1 1 5 1 0
Blood glucose increased 0 0 0 1 0 1 0 0
Haemoglobin decreased 4 0 0 2 0 6 0 0
Blood uric acid increased 1 0 0 0 0 1 0 0
Blood calcium decreased 3 0 0 2 0 5 0 0
Blood creatinine increased 3 0 0 1 0 4 0 0
Blood lactate dehydrogenase increased 3 0 0 1 0 4 0 0
WBC count increased 1 0 0 0 0 1 0 0
WBC count decreased 1 1 0 2 0 3 1 0
Platelets decreased 3 0 0 2 0 5 0 0
Transaminases increased 2 0 0 3 0 5 0 0