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Table 4 Dose volume histogram (DVH) analysis for photon and proton craniospinal irradiation (n = 18)

From: Comparison of therapeutic dosimetric data from passively scattered proton and photon craniospinal irradiations for medulloblastoma

Structure, DVH dose level (Gy) Photons Protons  P value, Wilcoxian Signed Rank test Significance level Sequential Bonferroni
Mean SD Mean SD
Esophagus        
20 65.87 23.54 3.89 7.68 9.82E-05 <0.01
15 96.68 5.12 8.73 12.53 9.80E-05 <0.01
10 98.09 3.26 14.76 16.59 9.75E-05 <0.01
5 99.61 0.98 24.67 21.28 9.80E-05 <0.01
Heart        
20 2.80 4.58 0.03 0.08 2.51E-04 <0.01
15 42.49 16.98 0.15 0.23 9.82E-05 <0.01
10 56.77 11.12 0.53 0.62 9.82E-05 <0.01
5 60.68 11.30 1.31 1.28 9.82E-05 <0.01
Kidneys        
20 2.03 1.91 0.60 0.82 3.15E-03 <0.01
15 4.11 2.81 2.49 2.34 1.07E-03 <0.01
10 5.92 3.68 5.53 4.70 2.50E-01 NS
5 8.89 4.95 10.58 7.95 6.24E-01 NS
Liver        
20 3.09 3.17 0.08 0.15 9.82E-05 <0.01
15 14.69 4.22 0.27 0.30 9.82E-05 <0.01
10 22.55 1.99 0.61 1.05 9.82E-05 <0.01
5 24.78 3.95 1.10 0.75 9.82E-05 <0.01
Lungs        
20 3.07 2.14 2.27 1.92 3.54E-02 < 0.05 *
15 6.03 2.92 4.87 3.24 6.14E-03 < 0.01
10 8.35 3.52 7.66 4.32 7.23E-02 NS
5 11.69 4.51 11.31 5.52 1.53E-01 NS
Thyroid        
20 11.91 21.19 0.00 0.00 6.10E-05 <0.01
15 66.16 30.19 0.00 0.00 9.80E-05 <0.01
10 80.97 21.53 0.00 0.00 9.48E-05 <0.01
5 92.50 10.68 0.51 0.76 9.65E-05 <0.01
  1. Note: The table lists mean V20, V15, V10, and V5 and standard deviation (SD) values for the esophagus, heart, kidneys, liver, lungs, and thyroid. Statistical results from the Wilcoxon signed rank test (i.e., p-value for 1-tailed Wilcoxon signed rank test) are listed. Results from the sequential Bonferroni procedure are also included; † and * indicate differences were significant at the 0.01 and 0.05 levels, respectively.
  2. For this study 5, 10, 15, and 20 Gy are equivalent to 21.4%, 42.7%, 64.1%, and 85.5% of the prescribed dose, respectively.