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Table 2 Dose volume histogram (DVH) analysis for photon and proton craniospinal irradiation (n = 18)

From: Comparison of therapeutic dosimetric data from passively scattered proton and photon craniospinal irradiations for medulloblastoma

Structure, DVH dose level (Gy) Photons Protons  P value, Wilcoxian Signed Rank test Significance level (P ≤ 0.05)
Mean SD Mean SD
CTV       
23.4 99.36 1.04 99.23 0.88 5.42E-01 NS
25 12.01 9.87 1.72 4.01 8.63E-04 <0.01
Spinal cord       
23.4 99.16 0.85 98.91 1.46 9.83E-01 NS
25 59.02 9.15 4.64 7.52 1.96E-04 <0.01
Optic chiasm       
23.4 100.00 0.00 100.00 0.00 n/a N/A
25 3.48 4.29 3.26 3.36 5.69E-01 NS
Cochlea       
23.4 99.96 0.16 99.00 3.09 1.56E-02 < 0.05
25 2.08 2.96 4.26 6.95 6.36E-01 NS
Brain stem       
23.4 98.51 3.20 98.96 1.76 8.39E-01 NS
25 0.68 1.39 1.70 7.61 3.12E-02 < 0.05
  1.  Note:  The table provides mean V23.4 and V25 and standard deviation (SD) values for the CTV and in-field organs for proton and photon therapy. Statistical results from Wilcoxon signed rank test (i.e., two-tailed P-value for Wilcoxon signed rank test) are also listed.
  2. For this study 23.4 and 25 Gy is equivalent to 100% and 106.8% of the prescribed dose, respectively.