You are viewing the site in preview mode

Skip to main content

Advertisement

Table 5 Comparison of published data with regard to patterns of failure in patients with glioblastoma

From: Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index

Author Year Number Treatment Dose (Gy) Margin (cm) Recurrence sites
Central In-field Marginal Distant
Nakagawa [7] 1998 38 3DCRT + ACNU 60–80 0–2 90%    5%
     90 0–2 46%††    8%
Lee [5] 1999 36 3DCRT 70–80 1.5 72% 17% 8% 3%
Chan [6] 2002 34 3DCRT 90 0.5 78% 13% 9%  
Chang [3] 2007 48 3DCRT ± chemo* 60 1 83% 6% 6% 4%
Brandes [16] 2009 95 3DCRT + TMZ 60 2–3 72%   6% 22%
Milano [15] 2010 54 3DCRT + TMZ 60 2–2.5 92%§   15% 13%
Minniti [14] 2010 105 3DCRT + TMZ 60 1–2 79% 6% 6% 14%
McDonald [13] 2011 41 (IMRT or 3DCRT) ± TMZ 60 0.8 78% 15% 5% 2%
This study 2012 58 3DCRT ± (ACNU or TMZ) 60 1.5–2 69% 16% 12% 3%
  1. *21/48 patients received adjuvant or concurrent chemotherapy (carmustine, procarbazine, and temozolomide).
  2. †5% were subependymal recurrences (did not apply to our classification method of recurrence sites).
  3. ††46% were subependymal recurrences (did not apply to our classification method of recurrence sites).
  4. §Insufficient data to apply to our classification method of recurrence sites.