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Table 1 Results of Growth Delay Assays

From: Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study

Schedule Time in days for tumors to grow from 200 to 600 mm3 Growth-AGD†† Delay NGD§ Endhancement Factorǁ
Allografts     
Control 8.8 ± 0.9 -   
PTK787 10.5 ± 0.5 1.7 - -
IR 17.2 ± 0.5 8.4 - -
PTK787+IR 22.8 ± 1.4 14.0 12.3 1.5
Spontanous Tumors     
Control 11.5 ± 0.8 - - -
PTK787 14.3 ± 1.5 2.8 - -
IR 31.6 ± 2.8 20.1 -  
PTK787+IR 41.9 ± 1.8 30.4 27.6 1.4
  1. Effect of PTK787 on the radioresponse of allograft and spontaenous tumors measured by tumor growth delay. For treatment schedules see Figure 1.
  2. ††Absolute tumor growth delay (AGD) caused by PTK787, IR, or their combination is defined as the time in days required for tumor to triple tumor size from 200 to 600 mm3 minus the time in days in untreated tumors.
  3. §Normalized tumor growth delay (NGD) is defined as the time in days for tumors to triple tumor size in the mice treated with the combination of PTK787 and IR minus the time in days to triple tumor size in mice treated with PTK787 alone.
  4. ǁEnhancement factors obtained by dividing NGD in mice treated with PTK787 plus IR by the AGD in mice treated with IR alone.