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Figure 2 | Radiation Oncology

Figure 2

From: Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study

Figure 2

Increased tumor hypoxia in response to PTK787-treatment. Immunohistochemical detection of tumor hypoxia with antibodies against endogenous Glut-1 or the exogenous 2-nitroimidazole hypoxia marker pimonidazole hydrochloride in NF9006-derived allografts and spontaneous mammary carcinomas. Mice with NF9006-derived allografts and spontaneous tumors were treated with PTK787 (100 mg/kg × 4). Mice were sacrificed and tumors were harvested on day 4 of treatment.

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