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Figure 1 | Radiation Oncology

Figure 1

From: Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study

Figure 1

Schematic synopsis of the study. Androgen-sensitive prostate carcinoma xenografts received combinations of androgen-deprivation therapy (ADT) and/or radiotherapy (RT) and were subjected functional magnetic resonance imaging (MRI) pre-treatment and 1 and 9 days after onset of treatment. Together with standard clinical parameters (prostate-specific antigen (PSA), tumor volumes) the functional MRI parameters reflecting structural composition (apparent diffusion coefficient (ADC)) and vascularization (Ktrans) were used as inputs in an artificial neural network to elucidate how these functional MRI parameters independently and combined affected the prediction of therapy response, as measured by the 30 days post-RT tumor volumes (V30).

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