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Table 5 Univariate analysis for grades 3-4 late subcutaneous toxicity in the whole series of patients (n = 26) and in patients who received higher doses of RT (n = 19)

From: Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy

  HR (95% CI) P
Whole series    
   Age 1.012 (0.975-1.012) 0.535
   Received dose 1.079 (0.980-1.189) 0.123
   Maximum dose 1.054 (0.991-1.121) 0.096
   Bra size 1.056 (1.003-1.111) 0.037
   Systemic treatment 1.084 (0.351-3.347) 0.888
   Low DSB-High RIA 1Gy 0.564 (0.233-1.370) 0.206
   Low DSB-High RIA 2Gy 0.510 (0.204-1.277) 0.150
   Low DSB-High RIA 8Gy 0.642 (0.270-1.523) 0.314
Higher dose (≥81.6Gy)    
   Low DSB-High RIA 1Gy 0.252 (0.077-0.826) 0.023
   Low DSB-High RIA 2Gy 0.197 (0.053-0.735) 0.016
   Low DSB-High RIA 8Gy 0.240 (0.074-0.778) 0.017
  1. Abbreviations: HR = hazard ratio; CI = confidence interval